Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7nsg
Q-score: 0.539
Baronina A, Pike ACW, Yu X, Dong YY, Shintre CA, Tessitore A, Chu A, Rotty B, Venkaya S, Mukhopadhyay SMM, Borkowska O, Chalk R, Shrestha L, Burgess-Brown NA, Edwards AM, Arrowsmith CH, Bountra C, Han S, Carpenter EP
To Be Published
- (-)-3-hydroxy-4,5,6,6a-tetrahydro-3ah-pyrrolo[3,4-d]isoxazole-6-carboxylic acid (172 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Excitatory amino acid transporter 3 (53 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Ternary complex of excitatory amino acid transporter 3 with inhibitor hip-b (160 kDa, Complex from Homo sapiens)
- (+)-3-hydroxy-4,5,6,6a-tetrahydro-3ah-pyrrolo[3,4-d]isoxazole-6-carboxylic acid (172 Da, Ligand)
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 6r7x
Q-score: 0.516
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Undecyl-maltoside (496 Da, Ligand)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (low Ca2+, closed form)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7y
Q-score: 0.417
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)
Resolution: 5.14 Å
EM Method: Single-particle
Fitted PDBs: 6r7z
Q-score: 0.269
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)