Cryo_EM structure of human FAN1 in complex with 5' flap DNA substrate
Aretz J, Jeyasankar G, Salerno-Kochan A, Thomsen M, Thieulin-Pardo G, Haque T, Monteagudo E, Felsenfeld D, Finley M, Vogt TF, Boudet J, Prasad BC
bioRxiv (2024) [ DOI: doi:10.1101/2024.10.09.617442 ]
- Dna (post-nick) (5 kDa, DNA from Homo sapiens)
- Fan1 (Complex from Homo sapiens)
- Fan1-dna complex (Complex)
- Dna (continuous) (9 kDa, DNA from Homo sapiens)
- Dna (pre-nick) (4 kDa, DNA from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Fanconi-associated nuclease 1 (72 kDa, Protein from Homo sapiens)
Cryo_EM structure of human FAN1 in complex with 5' flap DNA substrate and PCNA
Aretz J, Jeyasankar G, Salerno-Kochan A, Thomsen M, Thieulin-Pardo G, Haque T, Monteagudo E, Felsenfeld D, Finley M, Vogt TF, Boudet J, Prasad BC
bioRxiv (2024) [ DOI: doi:10.1101/2024.10.09.617442 ]
- Dna (pre-nick) (8 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Dna (continuous) (12 kDa, DNA from Homo sapiens)
- Dna (post-nick) (6 kDa, DNA from Homo sapiens)
- Ternary complex of fan1-pcna-dna (Complex)
- Fan1-pcna (Complex from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Fanconi-associated nuclease 1 (72 kDa, Protein from Homo sapiens)
Cryo_EM structure of human FAN1 R507H mutant in complex with 5' flap DNA substrate and PCNA
Aretz J, Jeyasankar G, Salerno-Kochan A, Thomsen M, Thieulin-Pardo G, Haque T, Monteagudo E, Felsenfeld D, Finley M, Vogt TF, Boudet J, Prasad BC
bioRxiv (2024) [ DOI: doi:10.1101/2024.10.09.617442 ]
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Ternary complex of fan1 r507h-pcna-dna (Complex)
- Calcium ion (40 Da, Ligand)
- Fanconi-associated nuclease 1 (114 kDa, Protein from Homo sapiens)
- Dna (post-nick) (6 kDa, DNA from Homo sapiens)
- Fan1 r507h-pcna (Complex from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Dna (continuous) (12 kDa, DNA from Homo sapiens)
- Dna (pre-nick) (8 kDa, DNA from Homo sapiens)
(CAG)2 DNA-bound MutSbeta in open form with kinked MSH2 clamp
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8rz7
Q-score: 0.292
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna_2 (18 kDa, DNA from Homo sapiens)
- Double stranded dna (Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna_1 (20 kDa, DNA from Homo sapiens)
- Dna mismatch repair protein (Complex from Homo sapiens)
- Mutsbeta-dna-adp complex (Complex)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
MutSbeta-ATPgS with straight MSH2 clamp
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8rz8
Q-score: 0.349
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Mutsbeta-atpgs complex (Complex from Homo sapiens)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
MutSbeta-ATPgS with kinked MSH2 clamp
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8rz9
Q-score: 0.332
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Mutsbeta-atpgs complex (Complex from Homo sapiens)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
cryo-EM Structure of Craf:14-3-3:Mek1
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 8chf
Q-score: 0.18
Dedden D, Nitsche J, Schneider EV, Thomsen M, Schwarz D, Leuthner B, Gradler U
J Mol Biol (2024) 436 pp. 168483-168483 [ DOI: doi:10.1016/j.jmb.2024.168483 Pubmed: 38331211 ]
- Complex of dimer phosphorylated c-raf kinase domain with 14-3-3 dimer and 2 subunits of mek1 containing ligand gdc-0623 (Complex from Homo sapiens)
- 14-3-3 protein zeta isoform x1 (28 kDa, Protein from Spodoptera frugiperda)
- Dual specificity mitogen-activated protein kinase kinase 1 (43 kDa, Protein from Homo sapiens)
- 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol (334 Da, Ligand)
- Raf proto-oncogene serine/threonine-protein kinase (73 kDa, Protein from Homo sapiens)
Cryo-EM structure of CRaf dimer with 14:3:3
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8cpd
Q-score: 0.399
Dedden D, Nitsche J, Schneider EV, Thomsen M, Schwarz D, Leuthner B, Gradler U
J Mol Biol (2024) 436 pp. 168483-168483 [ DOI: doi:10.1016/j.jmb.2024.168483 Pubmed: 38331211 ]
MutSbeta bound to (CAG)2 DNA (canonical form)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8olx
Q-score: 0.397
Lee JH, Thomsen M, Daub H, Thieulin-Pardo G, Steinbacher SC, Sztyler A, Dahiya V, Neudegger T, Dominguez C, Iyer RR, Wilkinson HA, Monteagudo E, Plotnikov NV, Felsenfeld DP, Haque TS, Finley M, Boudet J, Vogt TF, Prasad BC
bioRxiv (2024) [ DOI: doi:10.1101/2023.05.08.539930 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna (27-mer) (8 kDa, DNA from synthetic construct)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna (21-mer) (6 kDa, DNA from synthetic construct)
- Mutsbeta bound to (cag)2 dna (canonical form) (Complex from Homo sapiens)
DNA-free open form of MutSbeta
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8om5
Q-score: 0.3
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna-free open form of mutsbeta (Complex from Homo sapiens)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)