Structure of the human INTS9-INTS11-BRAT1 complex
Lin MH, Jensen MK, Elrod ND, Chu HF, Haseley M, Beam AC, Huang KL, Chiang W, Russell WK, Williams K, Proschel C, Wagner EJ, Tong L
Mol Cell (2024) 84 pp. 2900-2917.e10 [ DOI: doi:10.1016/j.molcel.2024.06.017 Pubmed: 39032490 ]
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Integrator complex subunit 11 (67 kDa, Protein from Homo sapiens)
- Complex of brat1-ints9-ints11 (230 kDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Brca1-associated atm activator 1 (88 kDa, Protein from Homo sapiens)
Structure of the Drosophila IntS11-CG7044(dBRAT1) complex
Lin MH, Jensen MK, Elrod ND, Chu HF, Haseley M, Beam AC, Huang KL, Chiang W, Russell WK, Williams K, Proschel C, Wagner EJ, Tong L
Mol Cell (2024) 84 pp. 2900-2917.e10 [ DOI: doi:10.1016/j.molcel.2024.06.017 Pubmed: 39032490 ]
- Complex of drosophila ints11 and cg7044 (180 kDa, Complex from Drosophila melanogaster)
- Fi02071p (113 kDa, Protein from Drosophila melanogaster)
- Integrator complex subunit 11 (67 kDa, Protein from Drosophila melanogaster)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of Lactococcus lactis pyruvate carboxylase with acetyl-CoA and cyclic di-AMP
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7zz8
Q-score: 0.521
Lopez-Alonso JP, Lazaro M, Gil-Carton D, Choi PH, Tong L, Valle M
Nat Commun (2022) 13 pp. 6185-6185 [ DOI: doi:10.1038/s41467-022-33987-2 Pubmed: 36261450 ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Pyruvate carboxylase with acetyl coenzyme a and cyclic di-amp (Cellular component from Lactococcus lactis)
- Acetyl coenzyme *a (809 Da, Ligand)
- (2r,3r,3as,5r,7ar,9r,10r,10as,12r,14ar)-2,9-bis(6-amino-9h-purin-9-yl)octahydro-2h,7h-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide (658 Da, Ligand)
- Pyruvic acid (88 Da, Ligand)
- Pyruvate carboxylase (127 kDa, Protein from Lactococcus lactis)
Cryo-EM structure of the SARS-CoV-2 spike glycoprotein in complex with all-trans retinoic acid
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7y42
Q-score: 0.473
Tong L, Wang L, Liao S, Xiao X, Qu J, Wu C, Zhu Y, Tai W, Huang Y, Wang P, Li L, Zhang R, Xiang Y, Cheng G
Mbio (2022) 13 pp. e0148522-e0148522 [ DOI: doi:10.1128/mbio.01485-22 Pubmed: 35862773 ]
- Retinoic acid (300 Da, Ligand)
- Sars-cov-2 spike glycoprotein in complex with atra (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6v4x
Q-score: 0.516
Sun Y, Zhang Y, Aik WS, Yang XC, Marzluff WF, Walz T, Dominski Z, Tong L
Science (2020) 367 pp. 700-703 [ Pubmed: 32029631 DOI: doi:10.1126/science.aaz7758 ]
- The core of metazoan replication-dependent histone pre-mrna 3'-end processing machinery (Complex from Homo sapiens)
- Cleavage and polyadenylation specificity factor subunit 2 (88 kDa, Protein from Homo sapiens)
- U7 snrna-associated sm-like protein lsm11 (28 kDa, Protein from Homo sapiens)
- U7 snrna (19 kDa, RNA from Homo sapiens)
- Cleavage and polyadenylation specificity factor subunit 3 (77 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Small nuclear ribonucleoprotein g (9 kDa, Protein from Homo sapiens)
- U7 snrna-associated sm-like protein lsm10 (14 kDa, Protein from Homo sapiens)
- Modified h2a pre-mrna (16 kDa, RNA from Mus musculus)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (10 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (16 kDa, Protein from Homo sapiens)
- Symplekin (120 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6urg
Q-score: 0.543
Zhang Y, Sun Y, Shi Y, Walz T, Tong L
Mol Cell (2020) 77 pp. 800- [ DOI: doi:10.1016/j.molcel.2019.11.005 Pubmed: 31810758 ]
- Pre-mrna 3' end processing protein wdr33 (67 kDa, Protein from Homo sapiens)
- Cleavage and polyadenylation specificity factor subunit 2 (88 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cleavage and polyadenylation specificity factor subunit 4 (28 kDa, Protein from Homo sapiens)
- The complex of human mpsf-cpsf100 pim (Complex from Homo sapiens)
- Cleavage and polyadenylation specificity factor subunit 1 (161 kDa, Protein from Homo sapiens)
Cryo-EM structure of human CPSF160-WDR33-CPSF30-PAS RNA-CstF77 complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6uro
Q-score: 0.348
Zhang Y, Sun Y, Shi Y, Walz T, Tong L
Mol Cell (2020) 77 pp. 800- [ DOI: doi:10.1016/j.molcel.2019.11.005 Pubmed: 31810758 ]
- Pre-mrna 3' end processing protein wdr33 (67 kDa, Protein from Homo sapiens)
- Cleavage stimulation factor subunit 3 (83 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Pas rna (14 kDa, RNA from Macaca mulatta polyomavirus 1)
- The complex of human mpsf-pas rna-cstf (Complex from Homo sapiens)
- Cleavage and polyadenylation specificity factor subunit 4 (28 kDa, Protein from Homo sapiens)
- Cleavage and polyadenylation specificity factor subunit 1 (161 kDa, Protein from Homo sapiens)
Cryo-EM structure of human ATP-citrate lyase in complex with inhibitor NDI-091143
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 6o0h
Q-score: 0.407
Wei J, Leit S, Kuai J, Therrien E, Rafi S, Harwood Jr HJ, DeLaBarre B, Tong L
Nature (2019) 568 pp. 566-570 [ DOI: doi:10.1038/s41586-019-1094-6 Pubmed: 30944472 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-citrate synthase (122 kDa, Protein from Homo sapiens)
- Protein-inhibitor complex (Complex from Homo sapiens)
- Methyl 3-chloro-5-[(4,6-difluoro[1,1'-biphenyl]-3-yl)sulfamoyl]-4-hydroxybenzoate (453 Da, Ligand)
Cryo-EM structure of human CPSF-160-WDR33-CPSF-30-PAS RNA complex at 3.4 A resolution
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6dnh
Q-score: 0.512
Sun Y, Zhang Y, Hamilton K, Manley JL, Shi Y, Walz T, Tong L
PNAS (2018) 115 pp. E1419-E1428 [ DOI: doi:10.1073/pnas.1718723115 Pubmed: 29208711 ]
- Rna (5'-r(p*ap*ap*up*ap*ap*ap*c)-3') (5 kDa, RNA from Simian virus 40)
- Aauaaa polyadenylation signal (5 kDa, Complex from Simian virus 40)
- Quaternary complex of human cpsf-160-wdr33-cpsf-30 with aauaaa polyadenylation signal (255 kDa, Complex)
- Pre-mrna 3' end processing protein wdr33 (67 kDa, Protein from Homo sapiens)
- Cpsf-30 (27 kDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cpsf-160-wdr33 (225 kDa, Complex from Homo sapiens)
- Cleavage and polyadenylation specificity factor subunit 1 (161 kDa, Protein from Homo sapiens)
- Cleavage and polyadenylation specificity factor subunit 4 (27 kDa, Protein from Homo sapiens)