SARS-CoV-2 S Omicron Spike B.1.1.529 - 3-P2G3 and 1-P5C3 Fabs (Global)
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 7qti
Q-score: 0.331
Fenwick C, Turelli P, Ni D, Perez L, Lau K, Herate C, Marlin R, Lana E, Pellaton C, Raclot C, Esteves-Leuenberger L, Campos J, Farina A, Fiscalini F, Dereuddre-Bosquet N, Relouzat F, Abdelnabi R, Foo CS, Neyts J, Leyssen P, Levy Y, Pojer F, Stahlberg H, LeGrand R, Trono D, Pantaleo G
Nat Microbiol (2022) 7 pp. 1376-1389 [ Pubmed: 35879526 DOI: doi:10.1038/s41564-022-01198-6 ]
- P5c3 light chain (23 kDa, Protein from Homo sapiens)
- Spike omicron trimer with fabs (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein,envelope glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- P5c3 heavy chain (23 kDa, Protein from Homo sapiens)
- P2g3 light chain (23 kDa, Protein from Homo sapiens)
- Omicron spike (Complex from Homo sapiens)
- Fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- P2g3 heavy chain (24 kDa, Protein from Homo sapiens)
SARS-CoV-2 S Omicron Spike B.1.1.529 - RBD up - 1-P2G3 and 1-P5C3 Fabs (Local)
Resolution: 4.01 Å
EM Method: Single-particle
Fitted PDBs: 7qtj
Q-score: 0.344
Fenwick C, Turelli P, Ni D, Perez L, Lau K, Herate C, Marlin R, Lana E, Pellaton C, Raclot C, Esteves-Leuenberger L, Campos J, Farina A, Fiscalini F, Dereuddre-Bosquet N, Relouzat F, Abdelnabi R, Foo CS, Neyts J, Leyssen P, Levy Y, Pojer F, Stahlberg H, LeGrand R, Trono D, Pantaleo G
Nat Microbiol (2022) 7 pp. 1376-1389 [ Pubmed: 35879526 DOI: doi:10.1038/s41564-022-01198-6 ]
- P5c3 light chain (23 kDa, Protein from Homo sapiens)
- Spike omicron trimer with fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- Surface glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- P2g3 light chain (23 kDa, Protein from Homo sapiens)
- P5c3 heavy chain (23 kDa, Protein from Homo sapiens)
- P2g3 heavy chain (24 kDa, Protein from Homo sapiens)
SARS-CoV-2 S Omicron Spike B.1.1.529 - RBD down - 1-P2G3 Fab (Local)
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 7qtk
Q-score: 0.393
Fenwick C, Turelli P, Ni D, Perez L, Lau K, Herate C, Marlin R, Lana E, Pellaton C, Raclot C, Esteves-Leuenberger L, Campos J, Farina A, Fiscalini F, Dereuddre-Bosquet N, Relouzat F, Abdelnabi R, Foo CS, Neyts J, Leyssen P, Levy Y, Pojer F, Stahlberg H, LeGrand R, Trono D, Pantaleo G
Nat Microbiol (2022) 7 pp. 1376-1389 [ Pubmed: 35879526 DOI: doi:10.1038/s41564-022-01198-6 ]
- Spike omicron trimer with fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- P2g3 heavy chain (24 kDa, Protein from Homo sapiens)
- Surface glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- P2g3 light chain (23 kDa, Protein from Homo sapiens)
P5C3 is a potent fab neutralizer
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7p40
Q-score: 0.308
Fenwick C, Turelli P, Perez L, Pellaton C, Esteves-Leuenberger L, Farina A, Campos J, Lana E, Fiscalini F, Raclot C, Pojer F, Lau K, Demurtas D, Descatoire M, Joo VS, Foglierini M, Noto A, Abdelnabi R, Foo CS, Vangeel L, Neyts J, Du W, Bosch BJ, Veldman G, Leyssen P, Thiel V, LeGrand R, Levy Y, Trono D, Pantaleo G
Cell Rep (2021) 37 pp. 109814-109814 [ Pubmed: 34599871 DOI: doi:10.1016/j.celrep.2021.109814 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Variable light chain p5c3 (vl) (23 kDa, Protein from Homo sapiens)
- Severe acute respiratory syndrome coronavirus 2 (Complex)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Variable heavy chain p5c3 (vh) (23 kDa, Protein from Homo sapiens)
- Fab (Complex from Homo sapiens)
the local resolution of Fab p5c3.
Fenwick C, Turelli P, Perez L, Pellaton C, Esteves-Leuenberger L, Farina A, Campos J, Lana E, Fiscalini F, Raclot C, Pojer F, Lau K, Demurtas D, Descatoire M, Joo VS, Foglierini M, Noto A, Abdelnabi R, Foo CS, Vangeel L, Neyts J, Du W, Bosch BJ, Veldman G, Leyssen P, Thiel V, LeGrand R, Levy Y, Trono D, Pantaleo G
Cell Rep (2021) 37 pp. 109814-109814 [ Pubmed: 34599871 DOI: doi:10.1016/j.celrep.2021.109814 ]
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7phg
Q-score: 0.354
Fenwick C, Turelli P, Perez L, Pellaton C, Esteves-Leuenberger L, Farina A, Campos J, Lana E, Fiscalini F, Raclot C, Pojer F, Lau K, Demurtas D, Descatoire M, Joo VS, Foglierini M, Noto A, Abdelnabi R, Foo CS, Vangeel L, Neyts J, Du W, Bosch BJ, Veldman G, Leyssen P, Thiel V, LeGrand R, Levy Y, Trono D, Pantaleo G
Cell Rep (2021) 37 pp. 109814-109814 [ Pubmed: 34599871 DOI: doi:10.1016/j.celrep.2021.109814 ]
- Light chain (11 kDa, Protein from Homo sapiens)
- Rbd fab (Complex from Homo sapiens)
- Surface glycoprotein (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain variable (13 kDa, Protein from Homo sapiens)