Human mitochondrial RNase Z with tRNA-His-CCA
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 9ey2
Q-score: 0.652
EMBO J (2024) 43 pp. 6573-6590 [ Pubmed: 39516281 DOI: doi:10.1038/s44318-024-00297-w ]
- Mt-trna-his-cca (22 kDa, RNA from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Trna methyltransferase 10 homolog c (42 kDa, Protein from Homo sapiens)
- Mt-trna-his (Complex from Homo sapiens)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
- Zinc phosphodiesterase elac protein 2 (89 kDa, Protein from Homo sapiens)
- Rnasez with mt-trna-his (250 kDa, Complex)
- Rnasez (Complex from Homo sapiens)
Human mitochondrial RNase Z with tRNA-His-CCA, SDR5C1/TRMT10C focus
Resolution: 1.9 Å
EM Method: Single-particle
Fitted PDBs: 9gch
Q-score: 0.737
EMBO J (2024) 43 pp. 6573-6590 [ Pubmed: 39516281 DOI: doi:10.1038/s44318-024-00297-w ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Mt-trna-his-cca (22 kDa, RNA from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Trna methyltransferase 10 homolog c (42 kDa, Protein from Homo sapiens)
- Mt-trna-his (Complex from Homo sapiens)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
- Rnasez with mt-trna-his (250 kDa, Complex)
- Rnasez (Complex from Homo sapiens)
Human mitochondrial RNase Z with tRNA-His
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 9ey0
Q-score: 0.546
EMBO J (2024) 43 pp. 6573-6590 [ Pubmed: 39516281 DOI: doi:10.1038/s44318-024-00297-w ]
- Mt-trna-his (22 kDa, RNA from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Trna methyltransferase 10 homolog c (42 kDa, Protein from Homo sapiens)
- Mt-trna-his (Complex from Homo sapiens)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
- Zinc phosphodiesterase elac protein 2 (89 kDa, Protein from Homo sapiens)
- Rnasez with mt-trna-his (250 kDa, Complex)
- Rnasez (Complex from Homo sapiens)
Human mitochondrial RNase Z with tRNA-His precursor
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9ey1
Q-score: 0.523
EMBO J (2024) 43 pp. 6573-6590 [ Pubmed: 39516281 DOI: doi:10.1038/s44318-024-00297-w ]
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Trna methyltransferase 10 homolog c (42 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Trna-his-trna-ser (40 kDa, RNA from Homo sapiens)
- Mt-trna-his (Complex from Homo sapiens)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
- Rnasez with mt-trna-his (250 kDa, Complex)
- Rnasez (Complex from Homo sapiens)
- Zinc phosphodiesterase elac protein 2 (89 kDa, Protein from Homo sapiens)
Human mitochondrial Lon protease with substrate in the ATPase domain
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7p09
Q-score: 0.534
Valentin Gese G, Shahzad S, Pardo-Hernandez C, Wramstedt A, Falkenberg M, Hallberg M
To Be Published
- Composite map of human mitochondrial lonp1 (591 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Lon protease homolog, mitochondrial (98 kDa, Protein from Homo sapiens)
- Unknown peptide from human mitochondrial transcription factor a (tfam) (954 Da, Protein from Homo sapiens)
Human mitochondrial Lon protease without substrate
Resolution: 4.11 Å
EM Method: Single-particle
Fitted PDBs: 7p0b
Q-score: 0.295
Valentin Gese G, Shahzad S, Pardo-Hernandez C, Wramstedt A, Falkenberg M, Hallberg M
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Lon protease homolog, mitochondrial (98 kDa, Protein from Homo sapiens)
- Human mitochondrial lonp1 g106p, r563w and k594m mutant (591 kDa, Complex from Homo sapiens)
Human mitochondrial Lon protease with substrate in the ATPase and protease domains
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 7p0m
Q-score: 0.522
Valentin Gese G, Shahzad S, Pardo-Hernandez C, Wramstedt A, Falkenberg M, Hallberg M
To Be Published
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Unknown peptide from human mitochondrial transcription factor a (tfam) (954 Da, Protein from Homo sapiens)
- Human mitochondrial lonp1 k898a mutant (591 kDa, Complex from Homo sapiens)
- Lon protease homolog, mitochondrial (99 kDa, Protein from Homo sapiens)