3D reconstruction of the cylindrical assembly of DnaJA2 delta G/F by imposing D5 symmetry
Resolution: 6.9 Å
EM Method: Single-particle
Fitted PDBs: 7zhs
Q-score: 0.121
Velasco-Carneros L, Cuellar J, Dublang L, Santiago C, Marechal JD, Martin-Benito J, Maestro M, Fernandez-Higuero JA, Orozco N, Moro F, Valpuesta JM, Muga A
Nat Commun (2023) 14 pp. 5436-5436 [ Pubmed: 37670029 DOI: doi:10.1038/s41467-023-41150-8 ]
Partial structure of tyrosine hydroxylase lacking the first 35 residues in complex with dopamine.
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7pim
Q-score: 0.213
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- Tyrosine 3-monooxygenase (38 kDa, Protein from Homo sapiens)
- Tyrosine hydroxylase lacking the first 35 residues in complex with its inhibitor dopamine (Complex from Homo sapiens)
- Regulatory domain alpha-helix (1 kDa, Protein from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
- L-dopamine (153 Da, Ligand)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6zn2
Q-score: 0.232
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- Tyrosine 3-monooxygenase (38 kDa, Protein from Homo sapiens)
- Ser-leu-ile-glu-asp-ala-arg-lys-glu-arg-glu-ala-ala-val-ala-ala-ala-ala (1 kDa, Protein from Homo sapiens)
- Tyrosine hydroxylase (Complex from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
- L-dopamine (153 Da, Ligand)
Full-length structure of the substrate-free tyrosine hydroxylase (apo-TH).
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7a2g
Q-score: 0.234
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- Water (18 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Tyrosine hydroxylase (Complex from Homo sapiens)
- Tyrosine 3-monooxygenase (47 kDa, Protein from Homo sapiens)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6zvp
Q-score: 0.22
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- L-dopamine (153 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Tyrosine 3-monooxygenase (51 kDa, Protein from Homo sapiens)
- Tyrosine hydroxylase in complex with dopamine (Complex from Homo sapiens)
Partial structure of the substrate-free tyrosine hydroxylase (apo-TH).
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6zzu
Q-score: 0.422
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- Water (18 Da, Ligand)
- Tyrosine 3-monooxygenase (38 kDa, Protein from Homo sapiens)
- Tyrosine hydroxylase (Complex from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
Resolution: 3.97 Å
EM Method: Single-particle
Fitted PDBs: 6qb8
Q-score: 0.258
Cuellar J, Ludlam WG, Tensmeyer NC, Aoba T, Dhavale M, Santiago C, Bueno-Carrasco MT, Mann MJ, Plimpton RL, Makaju A, Franklin S, Willardson BM, Valpuesta JM
Nat Commun (2019) 10 pp. 2865-2865 [ DOI: doi:10.1038/s41467-019-10781-1 Pubmed: 31253771 ]
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Cct:mlst8 complex (1 MDa, Complex from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)