1918 H1N1 Viral influenza polymerase heterotrimer with Nb8196 core
Resolution: 4.48 Å
EM Method: Single-particle
Fitted PDBs: 7nj3
Q-score: 0.151
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein, rna-directed rna polymerase catalytic subunit, polymerase basic protein 2 (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Nanobody8196 core (14 kDa, Protein from Camelidae mixed library)
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Nanobody8196 core (Complex from Camelidae mixed library)
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8196 (Complex)
- Rna (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8199 core
Resolution: 4.63 Å
EM Method: Single-particle
Fitted PDBs: 7nj5
Q-score: 0.167
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8199 core (Complex from Camelidae mixed library)
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8199 core (14 kDa, Protein from Camelidae mixed library)
- Polymerase acidic protein, rna-directed rna polymerase catalytic subunit, polymerase basic protein 2 (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8199 (Complex)
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8200 core
Resolution: 4.82 Å
EM Method: Single-particle
Fitted PDBs: 7nj7
Q-score: 0.148
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8200 (Complex)
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8200 core (15 kDa, Protein from Camelidae mixed library)
- Nb8200 core (Complex from Camelidae mixed library)
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit, polymerase acidic protein, polymerase basic protein 2 (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
1918 Influenza virus polymerase heterotirmer in complex with vRNA promoters and Nb8201
Resolution: 4.22 Å
EM Method: Single-particle
Fitted PDBs: 7nk1
Q-score: 0.084
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna-directed rna polymerase catalytic subunit (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nanobody8201 (Complex from Camelidae mixed library)
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2 (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8201 (Complex)
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nanobody8201 (14 kDa, Protein from Camelidae mixed library)
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8202 core
Resolution: 4.84 Å
EM Method: Single-particle
Fitted PDBs: 7nk2
Q-score: 0.145
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8202 (Complex)
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nanobody8202 (14 kDa, Protein from Camelidae mixed library)
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8202 core (Complex from Camelidae mixed library)
- Rna-directed rna polymerase catalytic subunit, polymerase acidic protein, polymerase basic protein 2 (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8206
Resolution: 4.07 Å
EM Method: Single-particle
Fitted PDBs: 7nka
Q-score: 0.251
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from synthetic construct)
- Rna (Complex from synthetic construct)
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8206 (Complex)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase heterotrimer (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,polymerase basic protein 2 (102 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8206 (14 kDa, Protein from Camelidae mixed library)
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from synthetic construct)
- Nb8206 (Complex from Camelidae mixed library)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8207
Resolution: 4.46 Å
EM Method: Single-particle
Fitted PDBs: 7nkc
Q-score: 0.122
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Nb8207 (15 kDa, Protein from Camelidae mixed library)
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from synthetic construct)
- Rna (Complex from synthetic construct)
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8207 (Complex)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase heterotrimer (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8207 (Complex from Camelidae mixed library)
- Polymerase basic protein 2,polymerase basic protein 2 (102 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from synthetic construct)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8209 core
Resolution: 4.67 Å
EM Method: Single-particle
Fitted PDBs: 7nki
Q-score: 0.151
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8209 (14 kDa, Protein from Camelidae mixed library)
- Nanobody8209 (Complex from Camelidae mixed library)
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase heterotrimer (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,polymerase basic protein 2 (102 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8190 (Complex)
Fan H, Walker AP, Carrique L, Keown JR, Serna Martin I, Karia D, Sharps J, Hengrung N, Pardon E, Steyaert J, Grimes JM, Fodor E
Nature (2019) 573 pp. 287-290 [ DOI: doi:10.1038/s41586-019-1530-7 Pubmed: 31485076 ]
Influenza B virus (B/Panama/45) polymerase Hetermotrimer in complex with 3'5' cRNA promoter
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6qwl
Q-score: 0.355
Fan H, Walker AP, Carrique L, Keown JR, Serna Martin I, Karia D, Sharps J, Hengrung N, Pardon E, Steyaert J, Grimes JM, Fodor E
Nature (2019) 573 pp. 287-290 [ DOI: doi:10.1038/s41586-019-1530-7 Pubmed: 31485076 ]
- Influenza b (panama/45) polymerase hetermotrimer in complex with 3'5' crna promoter (Complex from Influenza B virus (B/Panama/45/1990))
- Influenza b (panama/45) polymerase hetermotrimer in complex with 3'5' crna promoter (250 kDa, Complex)
- 5' crna (4 kDa, RNA from Influenza A virus)
- Polymerase basic protein 2 (89 kDa, Protein from Influenza B virus (strain B/Panama/45/1990))
- 3' crna (4 kDa, RNA from Influenza A virus)
- Rna-directed rna polymerase catalytic subunit (84 kDa, Protein from Influenza B virus (strain B/Panama/45/1990))
- Polymerase acidic protein (83 kDa, Protein from Influenza B virus (strain B/Panama/45/1990))
- Influenza b (panama/45) polymerase hetermotrimer in complex with 3'5' crna promoter (Complex from Influenza A virus)