1918 H1N1 Viral influenza polymerase heterotrimer with Nb8196 core
Resolution: 4.48 Å
EM Method: Single-particle
Fitted PDBs: 7nj3
Q-score: 0.151
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8196 (Complex)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nanobody8196 core (14 kDa, Protein from Camelidae mixed library)
- Rna (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Nanobody8196 core (Complex from Camelidae mixed library)
- Polymerase acidic protein, rna-directed rna polymerase catalytic subunit, polymerase basic protein 2 (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8199 core
Resolution: 4.63 Å
EM Method: Single-particle
Fitted PDBs: 7nj5
Q-score: 0.167
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein, rna-directed rna polymerase catalytic subunit, polymerase basic protein 2 (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8199 core (14 kDa, Protein from Camelidae mixed library)
- Nb8199 core (Complex from Camelidae mixed library)
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8199 (Complex)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8200 core
Resolution: 4.82 Å
EM Method: Single-particle
Fitted PDBs: 7nj7
Q-score: 0.148
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
- Rna-directed rna polymerase catalytic subunit, polymerase acidic protein, polymerase basic protein 2 (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8200 core (15 kDa, Protein from Camelidae mixed library)
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8200 (Complex)
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8200 core (Complex from Camelidae mixed library)
1918 Influenza virus polymerase heterotirmer in complex with vRNA promoters and Nb8201
Resolution: 4.22 Å
EM Method: Single-particle
Fitted PDBs: 7nk1
Q-score: 0.084
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8201 (Complex)
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nanobody8201 (Complex from Camelidae mixed library)
- Polymerase basic protein 2 (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nanobody8201 (14 kDa, Protein from Camelidae mixed library)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8202 core
Resolution: 4.84 Å
EM Method: Single-particle
Fitted PDBs: 7nk2
Q-score: 0.145
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8202 (Complex)
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
- Rna-directed rna polymerase catalytic subunit, polymerase acidic protein, polymerase basic protein 2 (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8202 core (Complex from Camelidae mixed library)
- Nanobody8202 (14 kDa, Protein from Camelidae mixed library)
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8206
Resolution: 4.07 Å
EM Method: Single-particle
Fitted PDBs: 7nka
Q-score: 0.251
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Polymerase heterotrimer (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8206 (Complex)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8206 (Complex from Camelidae mixed library)
- Polymerase basic protein 2,polymerase basic protein 2 (102 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (Complex from synthetic construct)
- Nb8206 (14 kDa, Protein from Camelidae mixed library)
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from synthetic construct)
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from synthetic construct)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8207
Resolution: 4.46 Å
EM Method: Single-particle
Fitted PDBs: 7nkc
Q-score: 0.122
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Polymerase heterotrimer (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8207 (Complex from Camelidae mixed library)
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8207 (Complex)
- Nb8207 (15 kDa, Protein from Camelidae mixed library)
- Polymerase basic protein 2,polymerase basic protein 2 (102 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (Complex from synthetic construct)
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from synthetic construct)
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from synthetic construct)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8209 core
Resolution: 4.67 Å
EM Method: Single-particle
Fitted PDBs: 7nki
Q-score: 0.151
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Polymerase heterotrimer (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8209 (14 kDa, Protein from Camelidae mixed library)
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,polymerase basic protein 2 (102 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8190 (Complex)
- Nanobody8209 (Complex from Camelidae mixed library)
Fan H, Walker AP, Carrique L, Keown JR, Serna Martin I, Karia D, Sharps J, Hengrung N, Pardon E, Steyaert J, Grimes JM, Fodor E
Nature (2019) 573 pp. 287-290 [ Pubmed: 31485076 DOI: doi:10.1038/s41586-019-1530-7 ]
Influenza B virus (B/Panama/45) polymerase Hetermotrimer in complex with 3'5' cRNA promoter
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6qwl
Q-score: 0.355
Fan H, Walker AP, Carrique L, Keown JR, Serna Martin I, Karia D, Sharps J, Hengrung N, Pardon E, Steyaert J, Grimes JM, Fodor E
Nature (2019) 573 pp. 287-290 [ Pubmed: 31485076 DOI: doi:10.1038/s41586-019-1530-7 ]
- Influenza b (panama/45) polymerase hetermotrimer in complex with 3'5' crna promoter (Complex from Influenza B virus (B/Panama/45/1990))
- 3' crna (4 kDa, RNA from Influenza A virus)
- Rna-directed rna polymerase catalytic subunit (84 kDa, Protein from Influenza B virus (strain B/Panama/45/1990))
- Influenza b (panama/45) polymerase hetermotrimer in complex with 3'5' crna promoter (Complex from Influenza A virus)
- Polymerase acidic protein (83 kDa, Protein from Influenza B virus (strain B/Panama/45/1990))
- Polymerase basic protein 2 (89 kDa, Protein from Influenza B virus (strain B/Panama/45/1990))
- 5' crna (4 kDa, RNA from Influenza A virus)
- Influenza b (panama/45) polymerase hetermotrimer in complex with 3'5' crna promoter (250 kDa, Complex)