S. cerevisiae Chs1 in complex with polyoxin B
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8k3p
Q-score: 0.437
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ DOI: doi:10.1038/s41467-023-40479-4 Pubmed: 37553334 ]
- S. cerevisiae chs1 in complex with polyoxin b (Complex from Saccharomyces cerevisiae)
- (2s)-2-[[(2s,3s,4s)-5-aminocarbonyloxy-2-azanyl-3,4-bis(oxidanyl)pentanoyl]amino]-2-[(2r,3s,4r,5r)-5-[5-(hydroxymethyl)-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]ethanoic acid (507 Da, Ligand)
- Chitin synthase 1 (133 kDa, Protein from Saccharomyces cerevisiae S288C)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
S. cerevisiae Chs1 in apo state
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8k3q
Q-score: 0.59
S. cerevisiae Chs1 in complex with UDP
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8k3t
Q-score: 0.42
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ DOI: doi:10.1038/s41467-023-40479-4 Pubmed: 37553334 ]
- Uridine-5'-diphosphate (404 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- S. cerevisiae chs1 in complex with udp (Complex from Saccharomyces cerevisiae)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
S. cerevisiae Chs1 in complex with UDP-GlcNAc
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8k3v
Q-score: 0.53
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ DOI: doi:10.1038/s41467-023-40479-4 Pubmed: 37553334 ]
- Magnesium ion (24 Da, Ligand)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- S. cerevisiae chs1 in complex with udp-glcnac (Complex from Saccharomyces cerevisiae)
- Uridine-diphosphate-n-acetylglucosamine (607 Da, Ligand)
S. cerevisiae Chs1 in complex with UDP-GlcNAc and GlcNAc
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 8k3w
Q-score: 0.496
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ DOI: doi:10.1038/s41467-023-40479-4 Pubmed: 37553334 ]
- Magnesium ion (24 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- S. cerevisiae chs1 in complex with udp-glcnac and glcnac (Complex from Saccharomyces cerevisiae)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
- Uridine-diphosphate-n-acetylglucosamine (607 Da, Ligand)
S. cerevisiae Chs1 in complex with Nikkomycin Z
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8k3x
Q-score: 0.524
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ DOI: doi:10.1038/s41467-023-40479-4 Pubmed: 37553334 ]
- (2s)-{[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name) (495 Da, Ligand)
- S. cerevisiae chs1 in complex with nikkomycin z (Complex from Saccharomyces cerevisiae)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
Structure of a fungal 1,3-beta-glucan synthase
Resolution: 2.47 Å
EM Method: Single-particle
Fitted PDBs: 8jzn
Q-score: 0.577
Zhao CR, You ZL, Chen DD, Hang J, Wang ZB, Ji M, Wang LX, Zhao P, Qiao J, Yun CH, Bai L
Sci Adv (2023) 9 pp. eadh7820-eadh7820 [ Pubmed: 37703377 DOI: doi:10.1126/sciadv.adh7820 ]
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- 1,3-beta-glucan synthase component fks1 (215 kDa, Protein from Saccharomyces cerevisiae)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Fks1 (215 MDa, Complex from Saccharomyces cerevisiae)
- Ergosterol (396 Da, Ligand)
S. cerevisiae Chs1 in complex with UDP and GlcNAc
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8k3u
Q-score: 0.445
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ DOI: doi:10.1038/s41467-023-40479-4 Pubmed: 37553334 ]
- Uridine-5'-diphosphate (404 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- S. cerevisiae chs1 in complex with udp and glcnac (Complex from Saccharomyces cerevisiae)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
S. cerevisiae Chs1 in apo state incubated with GlcNAc
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8k3r
Q-score: 0.412
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8a64
Q-score: 0.271
Trastoy B, Du JJ, Cifuente JO, Rudolph L, Garcia-Alija M, Klontz EH, Deredge D, Sultana N, Huynh CG, Flowers MW, Li C, Sastre DE, Wang LX, Corzana F, Mallagaray A, Sundberg EJ, Guerin ME
Nat Commun (2023) 14 pp. 1705-1705 [ DOI: doi:10.1038/s41467-023-37215-3 Pubmed: 36973249 ]