Cryo-EM structure of peptide free and Gs-coupled GIPR
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8wa3
Q-score: 0.464
Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW
Cell Discov (2024) 10 pp. 18-18 [ Pubmed: 38346960 DOI: doi:10.1038/s41421-024-00649-0 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Gastric inhibitory polypeptide receptor,fusion protein (64 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with gip and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,o-antigen polymerase (40 kDa, Protein from Leptolinea tardivitalis)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gy7
Q-score: 0.453
Luo P, Feng W, Ma S, Dai A, Wu K, Chen X, Yuan Q, Cai X, Yang D, Wang MW, Eric Xu H, Jiang Y
Cell Res (2023) 33 pp. 46-54 [ DOI: doi:10.1038/s41422-022-00751-6 Pubmed: 36588120 ]
- Mrap1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Acth (Complex from Homo sapiens)
- Corticotropin (2 kDa, Protein from synthetic construct)
- Acth-bound melanocortin-2 receptor in complex with mrap1 and gs protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Melanocortin-2 receptor accessory protein (20 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (41 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,adrenocorticotropic hormone receptor,melanocortin-2 receptor,adrenocorticotropic hormone receptor,adrenocorticotropic hormone receptor (67 kDa, Protein from Homo sapiens)
- Melanocortin-2 receptor (Complex from Homo sapiens)
Fentanyl-bound mu-opioid receptor-Gi complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ef5
Q-score: 0.39
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- N-phenyl-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide (336 Da, Ligand)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Morphine-bound mu-opioid receptor-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ef6
Q-score: 0.471
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- (7r,7as,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1h-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol (285 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
Oliceridine-bound mu-opioid receptor-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8efb
Q-score: 0.462
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- N-[(3-methoxythiophen-2-yl)methyl]-2-[(9r)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethan-1-amine (386 Da, Ligand)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
SR17018-bound mu-opioid receptor-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8efl
Q-score: 0.463
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- 5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-1,3-dihydro-2h-benzimidazol-2-one (410 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Scfv16 (26 kDa, Protein from Homo sapiens)
PZM21-bound mu-opioid receptor-Gi complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8efo
Q-score: 0.472
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- N-[(2s)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-n'-[(2s)-1-(thiophen-3-yl)propan-2-yl]urea (361 Da, Ligand)
- Cholesterol (386 Da, Ligand)
DAMGO-bound mu-opioid receptor-Gi complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8efq
Q-score: 0.42
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Ethanolamine (61 Da, Ligand)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Damgo (470 Da, Protein from synthetic construct)