Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xmr
Q-score: 0.41
Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q
Cell Res (2022) 32 pp. 761-772 [ DOI: doi:10.1038/s41422-022-00679-x Pubmed: 35739238 ]
- Somatostatin receptor type 2 (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Complex structure of the somatostatin receptor 2 (sstr2) in complex with gi1 and its endogeneous peptide ligand sst-14 (Complex from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7xms
Q-score: 0.408
Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q
Cell Res (2022) 32 pp. 761-772 [ DOI: doi:10.1038/s41422-022-00679-x Pubmed: 35739238 ]
- Signle chain viable fragment of antibody (31 kDa, Protein from Mus musculus)
- Complex structure of somatostatin receptor 4 (sstr4) in complex with gi and its endogeneous ligand sst-14 (Complex from Homo sapiens)
- Somatostatin receptor type 4 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
CryoEM structure of somatostatin receptor 4 (SSTR4) with Gi1 and J-2156
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7xmt
Q-score: 0.424
Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q
Cell Res (2022) 32 pp. 761-772 [ DOI: doi:10.1038/s41422-022-00679-x Pubmed: 35739238 ]
- Somatostatin receptor type 4 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (2~{s})-2-[[(2~{s})-4-azanyl-2-[(4-methylnaphthalen-1-yl)sulfonylamino]butanoyl]amino]-3-phenyl-propanimidic acid (468 Da, Ligand)
- Complex structure of somatostatin receptor 4 (sstr4) with gi and j-2156 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Single chain variable fragment of antibody (31 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gi
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7f8v
Q-score: 0.436
Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q
Nat Chem Biol (2021) 17 pp. 1230-1237 [ DOI: doi:10.1038/s41589-021-00866-8 Pubmed: 34556863 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Cholecystokinin type b receptor (Complex)
- Gastrin-17 (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit (Complex)
- Gastrin/cholecystokinin type b receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Gastrin-17 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholecystokinin recetor cckbr in complex with gastrin-17 and gi (Complex from Homo sapiens)
Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7f8w
Q-score: 0.335
Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q
Nat Chem Biol (2021) 17 pp. 1230-1237 [ DOI: doi:10.1038/s41589-021-00866-8 Pubmed: 34556863 ]
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Cholecystokinin type b receptor (Complex)
- Scfv16 (Complex from Homo sapiens)
- Gastrin-17 (2 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g subunits (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Gastrin-17 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholecystokinin recetor cckbr in complex with gastrin-17 and gq (Complex from Homo sapiens)
- Gastrin/cholecystokinin type b receptor (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7e9g
Q-score: 0.39
Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B
Nature (2021) 594 pp. 583-588 [ Pubmed: 34135510 DOI: doi:10.1038/s41586-021-03495-2 ]
- Complex of mglu2 homodimer with heterotrimeric gi1 protein in presence of antibodies (Complex from Homo sapiens)
- Dn13 (13 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 2 (90 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one (344 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (1s,2s,5r,6s)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (185 Da, Ligand)
Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu4
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7e9h
Q-score: 0.303
Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B
Nature (2021) 594 pp. 583-588 [ Pubmed: 34135510 DOI: doi:10.1038/s41586-021-03495-2 ]
- Metabotropic glutamate receptor 4 (99 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Complex of mglu4 homodimer with heterotrimeric gi3 protein in presence of antibody (Complex from Homo sapiens)
- Phosphoserine (185 Da, Ligand)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human glucagon receptor in complex with Gs
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6lmk
Q-score: 0.443
Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B
Science (2020) 367 pp. 1346-1352 [ Pubmed: 32193322 DOI: doi:10.1126/science.aaz5346 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Glucagon (3 kDa, Protein from Homo sapiens)
- Complex of glucagon receptor bound to glucagon, gs protein and nanobody (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glucagon receptor (48 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human glucagon receptor in complex with Gi1
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6lml
Q-score: 0.425
Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B
Science (2020) 367 pp. 1346-1352 [ Pubmed: 32193322 DOI: doi:10.1126/science.aaz5346 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Glucagon (3 kDa, Protein from Homo sapiens)
- Glucagon receptor (48 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Complex of glucagon receptor bound to glucagon, gi1 protein and antibody (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)