Cryo-EM structure of the SV1-Gs complex.
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7v9l
Q-score: 0.505
Cong Z, Zhou F, Zhang C, Zou X, Zhang H, Wang Y, Zhou Q, Cai X, Liu Q, Li J, Shao L, Mao C, Wang X, Wu J, Xia T, Zhao LH, Jiang H, Zhang Y, Xu HE, Cheng X, Yang D, Wang MW
PNAS (2021) 118 [ Pubmed: 34599099 DOI: doi:10.1073/pnas.2106606118 ]
- Nanobody 35 (15 kDa, Protein from synthetic construct)
- Cryo-em structure of the human growth hormone releasing hormone receptor splice variant 1 in complex with g protein (Complex from Homo sapiens)
- Ghrh receptor splice variant 1,ghrh receptor splice variant 1,ghrh receptor splice variant 1,sv1 (57 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7v9m
Q-score: 0.431
Cong Z, Zhou F, Zhang C, Zou X, Zhang H, Wang Y, Zhou Q, Cai X, Liu Q, Li J, Shao L, Mao C, Wang X, Wu J, Xia T, Zhao LH, Jiang H, Zhang Y, Xu HE, Cheng X, Yang D, Wang MW
PNAS (2021) 118 [ Pubmed: 34599099 DOI: doi:10.1073/pnas.2106606118 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Somatoliberin (5 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of the human growth hormone releasing hormone receptor splice variant 1 in complex with ghrh and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Human growth hormone releasing hormone receptor splice variant 1(sv1) (57 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7f16
Q-score: 0.415
Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2101279118 Pubmed: 34353904 ]
- Parathyroid hormone 2 receptor (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Nanobody-35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Tuberoinfundibular peptide of 39 residues (4 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and g protein (Complex from Homo sapiens)
Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7cz5
Q-score: 0.582
Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2020) 11 pp. 5205-5205 [ Pubmed: 33060564 DOI: doi:10.1038/s41467-020-18945-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
- Nanobody35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Somatoliberin (5 kDa, Protein from Homo sapiens)
- Hormone (Complex from Homo sapiens)
- Growth hormone-releasing hormone receptor,growth hormone-releasing hormone receptor (61 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- G(s) subunit beta-1 (Complex from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Growth hormone-releasing hormone receptor - gs protein complex (180 kDa, Complex)
- G(s) subunit gamma-2 (Complex from Bos taurus)
- Nanobody35 (13 kDa, Protein from synthetic construct)
- Hormone receptor, g(s) subunit alpha isoforms (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)