Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8xm6
Q-score: 0.435
Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q
EMBO Rep (2024) 25 pp. 5006-5025 [ DOI: doi:10.1038/s44319-024-00287-3 Pubmed: 39390258 ]
- Zinc ion (65 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Proton-coupled zinc antiporter slc30a1 (58 kDa, Protein from Homo sapiens)
- Zinc transporter 1 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8xma
Q-score: 0.538
Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q
EMBO Rep (2024) 25 pp. 5006-5025 [ DOI: doi:10.1038/s44319-024-00287-3 Pubmed: 39390258 ]
- Zinc ion (65 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Proton-coupled zinc antiporter slc30a1 (58 kDa, Protein from Homo sapiens)
- Zinc transporter 1 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8xmf
Q-score: 0.393
Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q
EMBO Rep (2024) 25 pp. 5006-5025 [ DOI: doi:10.1038/s44319-024-00287-3 Pubmed: 39390258 ]
- Zinc ion (65 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Proton-coupled zinc antiporter slc30a1 (58 kDa, Protein from Homo sapiens)
- Zinc transporter 1 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 4.18 Å
EM Method: Single-particle
Fitted PDBs: 8xmj
Q-score: 0.327
Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q
EMBO Rep (2024) 25 pp. 5006-5025 [ DOI: doi:10.1038/s44319-024-00287-3 Pubmed: 39390258 ]
- Zinc ion (65 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Proton-coupled zinc antiporter slc30a1 (58 kDa, Protein from Homo sapiens)
- Zinc transporter 1 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8xn1
Q-score: 0.482
Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q
EMBO Rep (2024) 25 pp. 5006-5025 [ DOI: doi:10.1038/s44319-024-00287-3 Pubmed: 39390258 ]
- Zinc ion (65 Da, Ligand)
- Zinc transporter 3 (Complex from Homo sapiens)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- Probable proton-coupled zinc antiporter slc30a3 (42 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of PI3Kalpha in complex with compound 17
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ils
Q-score: 0.541
Zhou Q, Liu X, Neri D, Li W, Favalli N, Bassi G, Yang S, Yang D, Vogt PK, Wang MW
PNAS (2023) 120 pp. e2304071120-e2304071120 [ DOI: doi:10.1073/pnas.2304071120 Pubmed: 37585458 ]
- N-[(2r)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide (528 Da, Ligand)
- Human pi3kalpha in complex with compound 17 (Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
Cryo-EM structure of PI3Kalpha in complex with compound 18
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8ilv
Q-score: 0.492
Zhou Q, Liu X, Neri D, Li W, Favalli N, Bassi G, Yang S, Yang D, Vogt PK, Wang MW
PNAS (2023) 120 pp. e2304071120-e2304071120 [ DOI: doi:10.1073/pnas.2304071120 Pubmed: 37585458 ]
- N-[(2r)-1-(ethylamino)-1-oxidanylidene-3-[3-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide (528 Da, Ligand)
- Human pi3kalpha in complex with compound 18 (Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
Cryo-EM structure of PI3Kalpha in complex with compound 16
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8ilr
Q-score: 0.506
Zhou Q, Liu X, Neri D, Li W, Favalli N, Bassi G, Yang S, Yang D, Vogt PK, Wang MW
PNAS (2023) 120 pp. e2304071120-e2304071120 [ DOI: doi:10.1073/pnas.2304071120 Pubmed: 37585458 ]
- Human pi3kalpha in complex with compound 16 (Complex from Homo sapiens)
- N-[(2s)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide (528 Da, Ligand)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
Cryo-EM structure of the INSL5-bound human relaxin family peptidereceptor 4(RXFP4)-Gi complex
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7yj4
Q-score: 0.429
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ Pubmed: 36717591 DOI: doi:10.1038/s41467-023-36182-z ]
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Insulin-like peptide insl5 a chain (2 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with insl5 and g protein (Complex)
- Insl5 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (Complex from synthetic construct)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Insulin-like peptide insl5 b chain (2 kDa, Protein from Homo sapiens)
- Human relaxin family peptide receptor 4 (Complex from Homo sapiens)
Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gy7
Q-score: 0.453
Luo P, Feng W, Ma S, Dai A, Wu K, Chen X, Yuan Q, Cai X, Yang D, Wang MW, Eric Xu H, Jiang Y
Cell Res (2023) 33 pp. 46-54 [ Pubmed: 36588120 DOI: doi:10.1038/s41422-022-00751-6 ]
- Acth-bound melanocortin-2 receptor in complex with mrap1 and gs protein (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (41 kDa, Protein from Homo sapiens)
- Melanocortin-2 receptor accessory protein (20 kDa, Protein from Homo sapiens)
- Acth (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Corticotropin (2 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Melanocortin-2 receptor (Complex from Homo sapiens)
- Soluble cytochrome b562,adrenocorticotropic hormone receptor,melanocortin-2 receptor,adrenocorticotropic hormone receptor,adrenocorticotropic hormone receptor (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Mrap1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)