H. sapiens MCM2-7 double hexamer bound to double stranded DNA
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8s09
Q-score: 0.448
Weissmann F, Greiwe JF, Puhringer T, Eastwood EL, Couves EC, Miller TCR, Diffley JFX, Costa A
Nature (2024) 636 pp. 499-508 [ Pubmed: 39604733 DOI: doi:10.1038/s41586-024-08263-6 ]
- Dna (45-mer) (13 kDa, DNA from synthetic construct)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna (45-mer) (13 kDa, DNA from synthetic construct)
- Zinc ion (65 Da, Ligand)
- Double stranded dna (Complex from synthetic construct)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- H. sapiens mcm2-7 (Complex from Homo sapiens)
- H. sapiens mcm2-7 double hexamer bound to double stranded dna (1 MDa, Complex)
H. sapiens MCM2-7 hexamer bound to double stranded DNA
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8s0a
Q-score: 0.442
Weissmann F, Greiwe JF, Puhringer T, Eastwood EL, Couves EC, Miller TCR, Diffley JFX, Costa A
Nature (2024) 636 pp. 499-508 [ Pubmed: 39604733 DOI: doi:10.1038/s41586-024-08263-6 ]
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- H. sapiens mcm2-7 hexamer bound to double stranded dna (600 kDa, Complex)
- Zinc ion (65 Da, Ligand)
- Double stranded dna (Complex from synthetic construct)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Dna (22-mer) (6 kDa, DNA from synthetic construct)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- H. sapiens mcm2-7 (Complex from Homo sapiens)
H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8s0b
Q-score: 0.377
Weissmann F, Greiwe JF, Puhringer T, Eastwood EL, Couves EC, Miller TCR, Diffley JFX, Costa A
Nature (2024) 636 pp. 499-508 [ Pubmed: 39604733 DOI: doi:10.1038/s41586-024-08263-6 ]
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna (45-mer) (13 kDa, DNA from synthetic construct)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Origin recognition complex subunit 6 (28 kDa, Protein from Homo sapiens)
- Dna (45-mer) (13 kDa, DNA from synthetic construct)
- Zinc ion (65 Da, Ligand)
- Double stranded dna (Complex from synthetic construct)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- H. sapiens mcm bound to double stranded dna and orc6 as part of the mcm-orc complex (600 kDa, Complex)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- H. sapiens mcm2-7 (Complex from Homo sapiens)
- H. sapiens orc6 (Complex from Homo sapiens)
H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8s0c
Q-score: 0.289
Weissmann F, Greiwe JF, Puhringer T, Eastwood EL, Couves EC, Miller TCR, Diffley JFX, Costa A
Nature (2024) 636 pp. 499-508 [ Pubmed: 39604733 DOI: doi:10.1038/s41586-024-08263-6 ]
- Dna (26-mer) (8 kDa, DNA from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Origin recognition complex subunit 5 (50 kDa, Protein from Homo sapiens)
- H. sapiens orc1-5 (Complex from Homo sapiens)
- Origin recognition complex subunit 4 (50 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 1 (97 kDa, Protein from Homo sapiens)
- H. sapiens orc1-5 bound to double stranded dna as part of the mcm-orc complex (400 kDa, Complex)
- Dna (26-mer) (7 kDa, DNA from synthetic construct)
- Double stranded dna (Complex from synthetic construct)
- Origin recognition complex subunit 2 (66 kDa, Protein from Homo sapiens)
- Isoform 2 of origin recognition complex subunit 3 (82 kDa, Protein from Homo sapiens)
H. sapiens MCM bound to double stranded DNA and ORC1-6
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8s0d
Q-score: 0.346
Weissmann F, Greiwe JF, Puhringer T, Eastwood EL, Couves EC, Miller TCR, Diffley JFX, Costa A
Nature (2024) 636 pp. 499-508 [ Pubmed: 39604733 DOI: doi:10.1038/s41586-024-08263-6 ]
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Origin recognition complex subunit 5 (50 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Origin recognition complex subunit 2 (66 kDa, Protein from Homo sapiens)
- H. sapiens mcm (Complex from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna (58-mer) (17 kDa, DNA from synthetic construct)
- H. sapiens orc6 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Isoform 2 of origin recognition complex subunit 3 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (101 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna (58-mer) (17 kDa, DNA from synthetic construct)
- Origin recognition complex subunit 6 (28 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- H. sapiens orc1-5 (Complex from Homo sapiens)
- Origin recognition complex subunit 4 (50 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 1 (97 kDa, Protein from Homo sapiens)
- Double stranded dna (Complex from synthetic construct)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- H. sapiens mcm bound to double stranded dna and orc1-6 (1 MDa, Complex)
H. sapiens OCCM bound to double stranded DNA
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8s0e
Q-score: 0.24
Weissmann F, Greiwe JF, Puhringer T, Eastwood EL, Couves EC, Miller TCR, Diffley JFX, Costa A
Nature (2024) 636 pp. 499-508 [ Pubmed: 39604733 DOI: doi:10.1038/s41586-024-08263-6 ]
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Origin recognition complex subunit 5 (50 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
- Dna replication factor cdt1 (60 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 2 (66 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 3 (82 kDa, Protein from Homo sapiens)
- Cell division control protein 6 homolog (62 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- H. sapiens occm bound to double stranded dna (1 MDa, Complex)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna (39-mer) (12 kDa, DNA from synthetic construct)
- Dna (39-mer) (12 kDa, DNA from synthetic construct)
- H. sapiens occm (Complex from Homo sapiens)
- Origin recognition complex subunit 4 (50 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 1 (97 kDa, Protein from Homo sapiens)
- Double stranded dna (Complex from synthetic construct)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
H. sapiens OC1M bound to double stranded DNA
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8s0f
Q-score: 0.212
Weissmann F, Greiwe JF, Puhringer T, Eastwood EL, Couves EC, Miller TCR, Diffley JFX, Costa A
Nature (2024) 636 pp. 499-508 [ Pubmed: 39604733 DOI: doi:10.1038/s41586-024-08263-6 ]
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Origin recognition complex subunit 5 (50 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
- Dna replication factor cdt1 (60 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 2 (66 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 3 (82 kDa, Protein from Homo sapiens)
- Dna (39-mer) (12 kDa, DNA from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- Dna (39-mer) (12 kDa, DNA from synthetic construct)
- H. sapiens oc1m bound to double stranded dna (1 MDa, Complex)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Origin recognition complex subunit 4 (50 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 1 (97 kDa, Protein from Homo sapiens)
- Double stranded dna (Complex from synthetic construct)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- H. sapiens oc1m (Complex from Homo sapiens)
H. sapiens MCM double hexamer containing the MCM5 R195A/L209G mutant
Weissmann F, Greiwe JF, Puhringer T, Eastwood EL, Couves EC, Miller TCR, Diffley JFX, Costa A
Nature (2024) 636 pp. 499-508 [ Pubmed: 39604733 DOI: doi:10.1038/s41586-024-08263-6 ]
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 5khu
Q-score: 0.167
Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA
Mol Cell (2016) 63 pp. 593-607 [ Pubmed: 27522463 DOI: doi:10.1016/j.molcel.2016.07.003 ]
Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA
Mol Cell (2016) 63 pp. 593-607 [ Pubmed: 27522463 DOI: doi:10.1016/j.molcel.2016.07.003 ]