Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA3.G57R
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9aug
Q-score: 0.436
Swanson OM, Zhang QE, Van Itallie E, Tian M, Brown AR, Harris C, Kapingidza AB, Rhodes B, Smith LM, Venkatayogi S, Cronin K, Frazier M, Parks R, Bar M, Jiang C, Martin Beem JS, Cheng HL, Davis J, McGovern K, Newman A, Edwards RJ, Cain D, Alam SM, Wiehe K, Saunders KO, Acharya P, Alt F, Haynes BF, Azoitei ML
Sci Transl Med (2025) 17 pp. eadr2218-eadr2218 [ Pubmed: 39772772 DOI: doi:10.1126/scitranslmed.adr2218 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Uca3.g57r heavy chain (25 kDa, Protein from Homo sapiens)
- Cryo-em structure of ch848.d949.10.17.gs-dh270.uca3.g57r (Complex from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Uca3.g57r light chain (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA3
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9auh
Q-score: 0.466
Swanson OM, Zhang QE, Van Itallie E, Tian M, Brown AR, Harris C, Kapingidza AB, Rhodes B, Smith LM, Venkatayogi S, Cronin K, Frazier M, Parks R, Bar M, Jiang C, Martin Beem JS, Cheng HL, Davis J, McGovern K, Newman A, Edwards RJ, Cain D, Alam SM, Wiehe K, Saunders KO, Acharya P, Alt F, Haynes BF, Azoitei ML
Sci Transl Med (2025) 17 pp. eadr2218-eadr2218 [ Pubmed: 39772772 DOI: doi:10.1126/scitranslmed.adr2218 ]
- Uca3 light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Uca3 heavy chain (24 kDa, Protein from Homo sapiens)
- Hiv-1 bg505 ds-sosip glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of ch848.d949.10.17.gs-dh270.uca3 (Complex from Human immunodeficiency virus 1)
Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA4
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9aui
Q-score: 0.451
Swanson OM, Zhang QE, Van Itallie E, Tian M, Brown AR, Harris C, Kapingidza AB, Rhodes B, Smith LM, Venkatayogi S, Cronin K, Frazier M, Parks R, Bar M, Jiang C, Martin Beem JS, Cheng HL, Davis J, McGovern K, Newman A, Edwards RJ, Cain D, Alam SM, Wiehe K, Saunders KO, Acharya P, Alt F, Haynes BF, Azoitei ML
Sci Transl Med (2025) 17 pp. eadr2218-eadr2218 [ Pubmed: 39772772 DOI: doi:10.1126/scitranslmed.adr2218 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 bg505 ds-sosip glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of ch848.d949.10.17.gs-dh270.uca4 (Complex from Human immunodeficiency virus 1)
- Uca4 heavy chain (24 kDa, Protein from Homo sapiens)
- Uca4 light chain (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6um5
Q-score: 0.347
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh270 uca3 fab bound to hiv-1 env ch848 10.17dt (360 kDa, Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (17 kDa, Protein from Human immunodeficiency virus 1)
- Ch848 10.17 dt gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Dh270 uca3 fab light chain (22 kDa, Protein from Homo sapiens)
- Dh270 uca3 fab heavy chain (25 kDa, Protein from Homo sapiens)
Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6um6
Q-score: 0.318
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh270.6 heavy chain (25 kDa, Protein from Homo sapiens)
- Complex of antibody dh270.6 with hiv-1 env ch848 10.17dt (360 kDa, Complex from Human immunodeficiency virus 1)
- Ch848 10.17dt gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Ch848 10.17dt gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Dh270.6 light chain (22 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6um7
Q-score: 0.301
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- Envelope glycoprotein gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Dh270.mu1 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Dh270.mu1 fab light chain (24 kDa, Protein from Homo sapiens)
- Complex of dh270.mu1 and ch848 10.17dt envelope (360 kDa, Complex from Human immunodeficiency virus 1)