Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA3.G57R
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9aug
Q-score: 0.436
Swanson OM, Zhang QE, Van Itallie E, Tian M, Brown AR, Harris C, Kapingidza AB, Rhodes B, Smith LM, Venkatayogi S, Cronin K, Frazier M, Parks R, Bar M, Jiang C, Martin Beem JS, Cheng HL, Davis J, McGovern K, Newman A, Edwards RJ, Cain D, Alam SM, Wiehe K, Saunders KO, Acharya P, Alt F, Haynes BF, Azoitei ML
Sci Transl Med (2025) 17 pp. eadr2218-eadr2218 [ DOI: doi:10.1126/scitranslmed.adr2218 Pubmed: 39772772 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Uca3.g57r heavy chain (25 kDa, Protein from Homo sapiens)
- Hiv-1 bg505 ds-sosip glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of ch848.d949.10.17.gs-dh270.uca3.g57r (Complex from Human immunodeficiency virus 1)
- Uca3.g57r light chain (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA3
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9auh
Q-score: 0.466
Swanson OM, Zhang QE, Van Itallie E, Tian M, Brown AR, Harris C, Kapingidza AB, Rhodes B, Smith LM, Venkatayogi S, Cronin K, Frazier M, Parks R, Bar M, Jiang C, Martin Beem JS, Cheng HL, Davis J, McGovern K, Newman A, Edwards RJ, Cain D, Alam SM, Wiehe K, Saunders KO, Acharya P, Alt F, Haynes BF, Azoitei ML
Sci Transl Med (2025) 17 pp. eadr2218-eadr2218 [ DOI: doi:10.1126/scitranslmed.adr2218 Pubmed: 39772772 ]
- Uca3 light chain (22 kDa, Protein from Homo sapiens)
- Hiv-1 bg505 ds-sosip glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of ch848.d949.10.17.gs-dh270.uca3 (Complex from Human immunodeficiency virus 1)
- Uca3 heavy chain (24 kDa, Protein from Homo sapiens)
- Hiv-1 bg505 ds-sosip glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA4
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9aui
Q-score: 0.451
Swanson OM, Zhang QE, Van Itallie E, Tian M, Brown AR, Harris C, Kapingidza AB, Rhodes B, Smith LM, Venkatayogi S, Cronin K, Frazier M, Parks R, Bar M, Jiang C, Martin Beem JS, Cheng HL, Davis J, McGovern K, Newman A, Edwards RJ, Cain D, Alam SM, Wiehe K, Saunders KO, Acharya P, Alt F, Haynes BF, Azoitei ML
Sci Transl Med (2025) 17 pp. eadr2218-eadr2218 [ DOI: doi:10.1126/scitranslmed.adr2218 Pubmed: 39772772 ]
- Uca4 heavy chain (24 kDa, Protein from Homo sapiens)
- Hiv-1 bg505 ds-sosip glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of ch848.d949.10.17.gs-dh270.uca4 (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Uca4 light chain (22 kDa, Protein from Homo sapiens)
Structure of SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 7sg4
Q-score: 0.355
Martinez DR, Schafer A, Gobeil S, Li D, De la Cruz G, Parks R, Lu X, Barr M, Stalls V, Janowska K, Beaudoin E, Manne K, Mansouri K, Edwards RJ, Cronin K, Yount B, Anasti K, Montgomery SA, Tang J, Golding H, Shen S, Zhou T, Kwong PD, Graham BS, Mascola JR, Montefiori DC, Alam SM, Sempowski G, Sempowski GD, Khurana S, Wiehe K, Saunders KO, Acharya P, Haynes BF, Baric RS
Sci Transl Med (2022) 14 pp. eabj7125-eabj7125 [ DOI: doi:10.1126/scitranslmed.abj7125 Pubmed: 34726473 ]
- Dh1047 heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Dh1047 light chain (24 kDa, Protein from Homo sapiens)
- Sars-cov s protein in complex with receptor binding domain antibody dh1047 (Complex from Severe acute respiratory syndrome-related coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Sci Transl Med (2022) 14 pp. eabo5598-eabo5598 [ Pubmed: 36070369 DOI: doi:10.1126/scitranslmed.abo5598 ]
- Hiv env ch505tfchim.6r.sosip.664.v4.1 trimer (Complex from Human immunodeficiency virus 2)
- Dh1024 antibody fab (Complex from Macaca mulatta)
- Dh1024 antibody fab light chain (Protein from Macaca mulatta)
- Complex of hiv env ch505tfchim.6r.sosip.664.v4.1 with dh1024 antibody fab (23 kDa, Complex from Human immunodeficiency virus 2)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 (Protein from Human immunodeficiency virus 2)
- Dh1024 antibody fab light chain (Complex from Macaca mulatta)
- Dh1024 antibody fab heavy chain (Complex from Macaca mulatta)
- Dh1024 antibody fab heavy chain (Protein from Macaca mulatta)
Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Sci Transl Med (2022) 14 pp. eabo5598-eabo5598 [ Pubmed: 36070369 DOI: doi:10.1126/scitranslmed.abo5598 ]
- Dh1025.1 antibody fab light chain (Complex from Macaca mulatta)
- Dh1025.1 antibody fab (Complex from Macaca mulatta)
- Dh1025.1 antibody fab heavy chain (Complex from Macaca mulatta)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 trimer (Complex from Human immunodeficiency virus 2)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 (Protein from Human immunodeficiency virus 1)
- Complex of hiv env ch505tfchim.6r.sosip.664.v4.1 with dh1025.1 antibody fab (23 kDa, Complex from Human immunodeficiency virus 2)
- Dh1025.1 antibody fab heavy chain (Protein from Macaca mulatta)
- Dh1025.1 antibody fab light chain (Protein from Macaca mulatta)
Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Sci Transl Med (2022) 14 pp. eabo5598-eabo5598 [ Pubmed: 36070369 DOI: doi:10.1126/scitranslmed.abo5598 ]
- Hiv env ch505tfchim.6r.sosip.664.v4.1 trimer (Complex from Human immunodeficiency virus 2)
- Complex of hiv env ch505tfchim.6r.sosip.664.v4.1 with dh1027 antibody fab (23 kDa, Complex from Human immunodeficiency virus 2)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 (Protein from Human immunodeficiency virus 1)
- Dh1027 antibody fab light chain (Complex from Macaca mulatta)
- Dh1027 antibody fab heavy chain (Protein from Macaca mulatta)
- Dh1027 antibody fab heavy chain (Complex from Macaca mulatta)
- Dh1027 antibody fab (Complex from Macaca mulatta)
- Dh1027 antibody fab light chain (Protein from Macaca mulatta)
Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Sci Transl Med (2022) 14 pp. eabo5598-eabo5598 [ Pubmed: 36070369 DOI: doi:10.1126/scitranslmed.abo5598 ]
- Dh1028 antibody fab heavy chain (Protein from Macaca mulatta)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 trimer (Complex from Human immunodeficiency virus 2)
- Complex of hiv env ch505tfchim.6r.sosip.664.v4.1 with dh1028 antibody fab (23 kDa, Complex from Human immunodeficiency virus 2)
- Dh1028 antibody fab light chain (Protein from Macaca mulatta)
- Dh1028 antibody fab light chain (Complex from Macaca mulatta)
- Dh1028 antibody fab heavy chain (Complex from Macaca mulatta)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 (Protein from Human immunodeficiency virus 1)
- Dh1028 antibody fab (Complex from Macaca mulatta)
Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Sci Transl Med (2022) 14 pp. eabo5598-eabo5598 [ Pubmed: 36070369 DOI: doi:10.1126/scitranslmed.abo5598 ]
- Dh950 antibody fab heavy chain (Complex from Homo sapiens)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 trimer (Complex from Human immunodeficiency virus 2)
- Complex of hiv env ch505tfchim.6r.sosip.664.v4.1 with dh950 antibody fab (23 kDa, Complex from Human immunodeficiency virus 2)
- Dh950 antibody fab heavy chain (Protein from Homo sapiens)
- Dh950 antibody fab (Complex from Homo sapiens)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 (Protein from Human immunodeficiency virus 1)
- Dh950 antibody fab light chain (Complex from Homo sapiens)
- Dh950 antibody fab light chain (Protein from Homo sapiens)