Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ Pubmed: 39213340 DOI: doi:10.1126/sciimmunol.adm7097 ]
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ Pubmed: 39213340 DOI: doi:10.1126/sciimmunol.adm7097 ]
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ Pubmed: 39213340 DOI: doi:10.1126/sciimmunol.adm7097 ]
GT1.1 SOSIP in complex with wk39 polyclonal antibodies from NHP DC8G (gp120GH and base epitopes)
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ Pubmed: 39213340 DOI: doi:10.1126/sciimmunol.adm7097 ]
GT1.1 SOSIP in complex with wk39 polyclonal antibodies from NHP DC8G (V1V2V3 and gp120GH epitopes)
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ Pubmed: 39213340 DOI: doi:10.1126/sciimmunol.adm7097 ]
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ Pubmed: 39213340 DOI: doi:10.1126/sciimmunol.adm7097 ]
- Gt1.1 sosip-cc2 in complex with wk80 polyclonal antibodies from nhp 8229 (v1v2v3, c3v5, cd4bs, gp41gh/fp and base epitopes) (Complex from Human immunodeficiency virus 1)
- Gt1.1 sosip-cc2 in complex with wk80 polyclonal antibodies from nhp 8229 (v1v2v3, c3v5, cd4bs, gp41gh/fp and base epitopes) (Complex from Macaca mulatta)
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ Pubmed: 39213340 DOI: doi:10.1126/sciimmunol.adm7097 ]
- Gt1.1 sosip-cc2 in complex with wk80 polyclonal antibodies from nhp 8239 (gp120gh, gp41gh/fp, cd4bs, and base epitopes) (Complex from Human immunodeficiency virus 1)
- Gt1.1 sosip-cc2 in complex with wk80 polyclonal antibodies from nhp 8239 (gp120gh, gp41gh/fp, cd4bs, and base epitopes) (Complex from Macaca mulatta)
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 8u1d
Q-score: 0.359
Saunders KO, Counts J, Thakur B, Stalls V, Edwards R, Manne K, Lu X, Mansouri K, Chen Y, Parks R, Barr M, Sutherland L, Bal J, Havill N, Chen H, Machiele E, Jamieson N, Hora B, Kopp M, Janowska K, Anasti K, Jiang C, Van Itallie E, Venkatayogi S, Eaton A, Henderson R, Barbosa C, Alam SM, Santra S, Weissman D, Moody MA, Cain DW, Tam YK, Lewis M, Williams WB, Wiehe K, Montefiori DC, Acharya P, Haynes BF
Cell (2024) 187 pp. 79-94.e24 [ Pubmed: 38181743 DOI: doi:10.1016/j.cell.2023.12.002 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh1285 light chain (25 kDa, Protein from Macaca mulatta)
- The complex of vaccine elicited cd4 binding site neutralizing antibody dh1285 fab with ch505m5chimer.6r.sosip.664v4.1 env (308 kDa, Complex)
- Envelope glycoprotein gp120 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (72 kDa, Protein from Human immunodeficiency virus 1)
- Dh1285 heavy chain (26 kDa, Protein from Macaca mulatta)
- Dh1285 heavy chain, dh1285 light chain (Complex from Macaca mulatta)
Cryo-EM structure of HIV-1 Env(CH848 10.17 DS.SOSIP_DT) in complex with DH1030.1 Fab
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 8dow
Q-score: 0.387
Gobeil SM, Janowska K, Stalls V, Mansouri K, Henderson RC, Edwards RJ, Wiehe K, Saunders K, Acharya P, Williams W, Haynes BF
To Be Published
- Envelope glycoprotein gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh1030.1 fab light chain (24 kDa, Protein from Macaca mulatta)
- Dh1030.1 fab heavy chain (24 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 env(ch848 10.17 ds.sosip_dt) in complex with dh1030.1 fab (Complex from Macaca mulatta)
Cryo-EM structure of HIV-1 Env(BG505.T332N SOSIP) in complex with DH1030.1 Fab
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8dp1
Q-score: 0.433
Gobeil SM, Janowska K, Stalls V, Mansouri K, Edwards RJ, Henderson RC, Wiehe K, Saunders K, Acharya P, Williams W, Haynes BF
To Be Published
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh1030.1 fab heavy chain (24 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Dh1030.1 fab light chain (24 kDa, Protein from Macaca mulatta)
- Hiv-1 env(bg505.t332n sosip) in complex with dh1030.1 fab (Complex from Macaca mulatta)