Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ DOI: doi:10.1126/sciimmunol.adm7097 Pubmed: 39213340 ]
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ DOI: doi:10.1126/sciimmunol.adm7097 Pubmed: 39213340 ]
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ DOI: doi:10.1126/sciimmunol.adm7097 Pubmed: 39213340 ]
GT1.1 SOSIP in complex with wk39 polyclonal antibodies from NHP DC8G (gp120GH and base epitopes)
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ DOI: doi:10.1126/sciimmunol.adm7097 Pubmed: 39213340 ]
GT1.1 SOSIP in complex with wk39 polyclonal antibodies from NHP DC8G (V1V2V3 and gp120GH epitopes)
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ DOI: doi:10.1126/sciimmunol.adm7097 Pubmed: 39213340 ]
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ DOI: doi:10.1126/sciimmunol.adm7097 Pubmed: 39213340 ]
- Gt1.1 sosip-cc2 in complex with wk80 polyclonal antibodies from nhp 8229 (v1v2v3, c3v5, cd4bs, gp41gh/fp and base epitopes) (Complex from Human immunodeficiency virus 1)
- Gt1.1 sosip-cc2 in complex with wk80 polyclonal antibodies from nhp 8229 (v1v2v3, c3v5, cd4bs, gp41gh/fp and base epitopes) (Complex from Macaca mulatta)
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR
Sci Immunol (2024) 9 pp. eadm7097-eadm7097 [ DOI: doi:10.1126/sciimmunol.adm7097 Pubmed: 39213340 ]
- Gt1.1 sosip-cc2 in complex with wk80 polyclonal antibodies from nhp 8239 (gp120gh, gp41gh/fp, cd4bs, and base epitopes) (Complex from Macaca mulatta)
- Gt1.1 sosip-cc2 in complex with wk80 polyclonal antibodies from nhp 8239 (gp120gh, gp41gh/fp, cd4bs, and base epitopes) (Complex from Human immunodeficiency virus 1)
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 8u1d
Q-score: 0.359
Saunders KO, Counts J, Thakur B, Stalls V, Edwards R, Manne K, Lu X, Mansouri K, Chen Y, Parks R, Barr M, Sutherland L, Bal J, Havill N, Chen H, Machiele E, Jamieson N, Hora B, Kopp M, Janowska K, Anasti K, Jiang C, Van Itallie E, Venkatayogi S, Eaton A, Henderson R, Barbosa C, Alam SM, Santra S, Weissman D, Moody MA, Cain DW, Tam YK, Lewis M, Williams WB, Wiehe K, Montefiori DC, Acharya P, Haynes BF
Cell (2024) 187 pp. 79-94.e24 [ DOI: doi:10.1016/j.cell.2023.12.002 Pubmed: 38181743 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh1285 light chain (25 kDa, Protein from Macaca mulatta)
- Dh1285 heavy chain, dh1285 light chain (Complex from Macaca mulatta)
- The complex of vaccine elicited cd4 binding site neutralizing antibody dh1285 fab with ch505m5chimer.6r.sosip.664v4.1 env (308 kDa, Complex)
- Envelope glycoprotein gp120 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (72 kDa, Protein from Human immunodeficiency virus 1)
- Dh1285 heavy chain (26 kDa, Protein from Macaca mulatta)
Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7n28
Q-score: 0.385
Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C, Zhou T, Yu X, Gao F
Adv Sci (2022) 9 pp. e2200063-e2200063 [ DOI: doi:10.1002/advs.202200063 Pubmed: 35319830 ]
- Phosphate ion (94 Da, Ligand)
- J033 antibody heavy chain (24 kDa, Protein from Macaca mulatta)
- 3bnc117 antibody heavy chain (24 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
- A complex of hiv-1 env with antibodies 3bnc117 and j033 (Complex from Homo sapiens)
- J033 antibody light chain (23 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (19 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 3bnc117 antibody light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J038 in complex with HIV-1 Env
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7mxd
Q-score: 0.47
Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C, Zhou T, Yu X, Gao F
Adv Sci (2022) 9 pp. e2200063-e2200063 [ DOI: doi:10.1002/advs.202200063 Pubmed: 35319830 ]
- Phosphate ion (94 Da, Ligand)
- 3bnc117 antibody heavy chain (24 kDa, Protein from Homo sapiens)
- J038 antibody heavy chain (24 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- A complex of hiv-1 env with antibodies 3bnc117 and j038 (Complex from Homo sapiens)
- J038 antibody light chain (23 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 3bnc117 antibody light chain (23 kDa, Protein from Homo sapiens)