TRIF TIR Filament Cryo-EM Structure
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 9dk8
Q-score: 0.47
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 9cjk
Q-score: 0.344
Xiao L, Pi X, Goss AC, El-Baba T, Ehrmann JF, Grinkevich E, Bazua-Valenti S, Padovano V, Alper SL, Carey D, Udeshi ND, Carr SA, Pablo JL, Robinson CV, Greka A, Wu H
Sci Adv (2024) 10 pp. eadp2221-eadp2221 [ DOI: doi:10.1126/sciadv.adp2221 Pubmed: 39303030 ]
- Tmed9 octamer (Complex from Homo sapiens)
- Transmembrane emp24 domain-containing protein 9 (27 kDa, Protein from Homo sapiens)
- [(2r)-2-[(e)-octadec-9-enoyl]oxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] (e)-octadec-9-enoate (1 kDa, Ligand)
Caspase and interleukin complex
Devant P, Dong Y, Mintseris J, Ma W, Gygi SP, Wu H, Kagan JC
Nature (2023) 624 pp. 451-459 [ Pubmed: 37993712 DOI: doi:10.1038/s41586-023-06751-9 ]
- Caspase in complex with interleukin (144 kDa, Complex from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8spb
Q-score: 0.415
Devant P, Dong Y, Mintseris J, Ma W, Gygi SP, Wu H, Kagan JC
Nature (2023) 624 pp. 451-459 [ Pubmed: 37993712 DOI: doi:10.1038/s41586-023-06751-9 ]
- Caspase-4 subunit p20 (23 kDa, Protein from Homo sapiens)
- Caspase-4 subunit p10 (10 kDa, Protein from Homo sapiens)
- Caspase-4 in complex with pro-il-18 (144 kDa, Complex from Homo sapiens)
- Interleukin-18 (21 kDa, Protein from Homo sapiens)
Cryo-EM structure of the unliganded form of NLR family apoptosis inhibitory protein 5 (NAIP5)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7rav
Q-score: 0.347
Paidimuddala B, Cao J, Nash G, Xie Q, Wu H, Zhang L
Nat Struct Mol Biol (2023) 30 pp. 159-166 [ Pubmed: 36604500 DOI: doi:10.1038/s41594-022-00889-2 ]
- Baculoviral iap repeat-containing protein 1e (161 kDa, Protein from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Pre-liganded form of naip5 (Cell from Mus musculus)
Paidimuddala B, Cao J, Nash G, Xie Q, Wu H, Zhang L
Nat Struct Mol Biol (2023) 30 pp. 159-166 [ Pubmed: 36604500 DOI: doi:10.1038/s41594-022-00889-2 ]
Cryo-EM structure of the active NLRP3 inflammasome disk
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ej4
Q-score: 0.285
Nature (2023) 613 pp. 595-600 [ Pubmed: 36442502 DOI: doi:10.1038/s41586-022-05570-8 ]
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Nacht, lrr and pyd domains-containing protein 3 (102 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase nek7 (32 kDa, Protein from Homo sapiens)
- A complex of nlrp3 and nek7 (Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ert
Q-score: 0.48
Nature (2023) 613 pp. 595-600 [ Pubmed: 36442502 DOI: doi:10.1038/s41586-022-05570-8 ]
Structure of lysosomal membrane protein
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7lf6
Q-score: 0.307
Human TRPM2 ion channel in amphipol (apo state)
To Be Published