The structure of the core of the pyruvate dehydrogenase complex in the mitochondria of pig hearts.
Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 440-2 and 454-3
Silmon de Monerri NC, Che Y, Lees JA, Jasti J, Wu H, Griffor MC, Kodali S, Hawkins JC, Lypowy J, Ponce C, Curley K, Esadze A, Carcamo J, McLellan T, Keeney D, Illenberger A, Matsuka YV, Shanker S, Chorro L, Gribenko AV, Han S, Anderson AS, Donald RGK
PLoS Pathog (2025) 21 pp. e1012325-e1012325 [ Pubmed: 39970181 DOI: doi:10.1371/journal.ppat.1012325 ]
- 440-2 fab light chain (24 kDa, Protein from Mus musculus)
- 440-2 fab heavy chain (24 kDa, Protein from Mus musculus)
- 445-3 fab heavy chain (24 kDa, Protein from Mus musculus)
- 445-3 fab light chain (23 kDa, Protein from Mus musculus)
- Type 1 fimbrin d-mannose specific adhesin fimh, donor strand complemented with fimg peptide 'triple mutant' (32 kDa, Protein from Escherichia coli)
- Fimh-dsg tm in complex with fabs 440-2 and 445-3 (Complex)
- Fimh-dsg tm (Complex from Escherichia coli)
- Fab 445-3 (Complex from Mus musculus)
- Fab 440-2 (Complex from Mus musculus)
Cryo-EM Structure of Human Ninjurin1 curved oligomer
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8uip
Q-score: 0.046
David L, Borges JP, Hollingsworth LR, Volchuk A, Jansen I, Garlick E, Steinberg BE, Wu H
Cell (2024) 187 pp. 2224-2235.e16 [ Pubmed: 38614101 DOI: doi:10.1016/j.cell.2024.03.008 ]
- Ninjurin-1 (16 kDa, Protein from Homo sapiens)
- Ninjurin 1 ring oligomer (Complex from Homo sapiens)
Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8flk
Q-score: 0.438
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ Pubmed: 37828400 DOI: doi:10.1038/s41589-023-01434-y ]
- Sting tetramer (300 kDa, Complex from Homo sapiens)
- Cgamp (674 Da, Ligand)
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
Dong Y, Pi X, Bartels-Burgahn F, Saltukoglu D, Liang Z, Yang J, Alt FW, Reth M, Wu H
Nature (2022) 612 pp. 156-161 [ Pubmed: 36228656 DOI: doi:10.1038/s41586-022-05412-7 ]
- Bcr complex (Complex from Mus musculus)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8e4c
Q-score: 0.232
Dong Y, Pi X, Bartels-Burgahn F, Saltukoglu D, Liang Z, Yang J, Alt FW, Reth M, Wu H
Nature (2022) 612 pp. 156-161 [ Pubmed: 36228656 DOI: doi:10.1038/s41586-022-05412-7 ]
- B-cell antigen receptor complex-associated protein beta chain (25 kDa, Protein from Mus musculus)
- Isoform 2 of immunoglobulin heavy constant mu (45 kDa, Protein from Mus musculus)
- B-cell antigen receptor complex-associated protein alpha chain,yellow fluorescent protein (42 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bcr complex (Complex from Mus musculus)
Cryo-EM structure of BCL10 R58Q filament
Resolution: 4.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 8czd
Q-score: 0.224
Xia M, David L, Teater M, Gutierrez J, Wang X, Meydan C, Lytle A, Slack GW, Scott DW, Morin RD, Onder O, Elenitoba-Johnson KSJ, Zamponi N, Cerchietti L, Lu T, Philippar U, Fontan L, Wu H, Melnick AM
Cancer Discov (2022) 12 pp. 1922-1941 [ DOI: doi:10.1158/2159-8290.CD-21-1566 Pubmed: 35658124 ]
- B-cell lymphoma/leukemia 10 (12 kDa, Protein from Homo sapiens)
- Filament (Complex from Homo sapiens)
Cryo-EM structure of BCL10 CARD - MALT1 DD filament
Resolution: 4.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8czo
Q-score: 0.214
Xia M, David L, Teater M, Gutierrez J, Wang X, Meydan C, Lytle A, Slack GW, Scott DW, Morin RD, Onder O, Elenitoba-Johnson KSJ, Zamponi N, Cerchietti L, Lu T, Philippar U, Fontan L, Wu H, Melnick AM
Cancer Discov (2022) 12 pp. 1922-1941 [ DOI: doi:10.1158/2159-8290.CD-21-1566 Pubmed: 35658124 ]
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (10 kDa, Protein from Homo sapiens)
- B-cell lymphoma/leukemia 10 (12 kDa, Protein from Homo sapiens)
- Filament (Complex from Homo sapiens)
PSI-NDH supercomplex of Barley
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7f9o
Q-score: 0.153
Shen L, Tang K, Wang W, Wang C, Wu H, Mao Z, An S, Chang S, Kuang T, Shen JR, Han G, Zhang X
Nature (2022) 601 pp. 649-654 [ Pubmed: 34879391 DOI: doi:10.1038/s41586-021-04277-6 ]
- Photosystem i p700 chlorophyll a apoprotein a1 (83 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosynthetic ndh subunit of subcomplex b5 (18 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosystem i reaction center subunit iv, chloroplastic (15 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosystem i reaction center subunit ix (4 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosystem i reaction center subunit ii, chloroplastic (21 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Chlorophyll a-b binding protein, chloroplastic (27 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosynthetic ndh subunit of subcomplex b1 (51 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Beta-carotene (536 Da, Ligand)
- Photosystem i iron-sulfur center (8 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosystem i reaction center subunit xi, chloroplastic (22 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Chlorophyll a-b binding protein, chloroplastic (23 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosystem i reaction center subunit psak, chloroplastic (13 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- 1,2-distearoyl-monogalactosyl-diglyceride (787 Da, Ligand)
- (3s,5r,6s,3's,5'r,6's)-5,6,5',6'-diepoxy-5,6,5',6'- tetrahydro-beta,beta-carotene-3,3'-diol (600 Da, Ligand)
- Photosynthetic ndh subunit of subcomplex l2 (24 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- 1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
- Unidentified stromal protein (5 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosynthetic ndh subunit of subcomplex l1 (17 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosynthetic ndh subunit of subcomplex b3 (13 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosynthetic ndh subunit of subcomplex l4 (13 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Psi-ndh supercomplex of barley (Complex from Hordeum vulgare subsp. spontaneum)
- Chlorophyll a-b binding protein lhca5 (27 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosystem i p700 chlorophyll a apoprotein a2 (82 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
- Chlorophyll b (907 Da, Ligand)
- Nad(p)h-quinone oxidoreductase subunit 1, chloroplastic (38 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Chlorophyll a-b binding protein lhca1 (26 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Nad(p)h-quinone oxidoreductase subunit m, chloroplastic (24 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Chlorophyll a-b binding protein, chloroplastic (29 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Nad(p)h-quinone oxidoreductase subunit n, chloroplastic (25 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Nad(p)h-quinone oxidoreductase subunit 6, chloroplastic (19 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosystem i reaction center subunit viii (4 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosynthetic ndh subunit of subcomplex l5 (25 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Nad(p)h-quinone oxidoreductase subunit 2, chloroplastic (53 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Phylloquinone (450 Da, Ligand)
- Chlorophyll a-b binding protein lhca4 (21 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosystem i reaction center subunit vi, chloroplastic (14 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosynthetic ndh subunit of subcomplex b4 (9 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Nad(p)h-quinone oxidoreductase subunit h, chloroplastic (44 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- 1,2-di-o-acyl-3-o-[6-deoxy-6-sulfo-alpha-d-glucopyranosyl]-sn-glycerol (795 Da, Ligand)
- Nad(p)h-quinone oxidoreductase subunit j, chloroplastic (18 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Chlorophyll a (893 Da, Ligand)
- Photosynthetic ndh subunit of subcomplex b2 (38 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- (3r,3'r,6s)-4,5-didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol (568 Da, Ligand)
- Nad(p)h-quinone oxidoreductase subunit i, chloroplastic (19 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosystem i reaction center subunit iii, chloroplastic (24 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Nad(p)h-quinone oxidoreductase subunit 3, chloroplastic (13 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Nad(p)h-quinone oxidoreductase subunit k, chloroplastic (27 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Nad(p)h-quinone oxidoreductase chain 4, chloroplastic (56 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Nad(p)h-quinone oxidoreductase subunit l, chloroplastic (22 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Photosynthetic ndh subunit of subcomplex l2 (23 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-plastoquinone oxidoreductase subunit 5 (87 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Nad(p)h-quinone oxidoreductase subunit 4l, chloroplastic (11 kDa, Protein from Hordeum vulgare subsp. spontaneum)
- Chlorophyll a isomer (893 Da, Ligand)