Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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author:"Wu H" AND resolution:[4 TO 5} AND sample_type:"sample"

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EMD-3241

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Cryo-EM reconstruction of caspase-1 CARD

Release date: March 30, 2016
Resolution: 4.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 5fna
Q-score: 0.231

Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu T-M, Tong AB, Ploegh HL, Mao Y, Wu H

Nat Struct Mol Biol (2016) 23 pp. 416-425 [ DOI: doi:10.1038/nsmb.3199 Pubmed: 27043298 ]

Sample:

Caspase-1 card (Protein from Homo sapiens)
Human caspase-1 card (Sample)

EMD-6489

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Cryo-electron microscopy structure of RAG PC (with NBD, no symmetry)

Release date: Nov. 18, 2015
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 3jbw
Q-score: 0.245

Ru H, Chambers MG, Fu TM, Tong AB, Liao M, Wu H

Cell (2015) 163 pp. 1138-1152 [ Pubmed: 26548953 DOI: doi:10.1016/j.cell.2015.10.055 ]

Sample:

Recombination activating gene 1 and 2 (400 kDa, Protein from Danio rerio)
Paired complex of rag1-rag2 (400 kDa, Sample)

EMD-6458

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Cryo-EM Structure of the Activated NAIP2/NLRC4 Inflammasome Reveals Nucleated Polymerization

Release date: Oct. 21, 2015
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 3jbl
Q-score: 0.116

Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H

Science (2015) 350 pp. 404-409 [ Pubmed: 26449474 DOI: doi:10.1126/science.aac5789 ]

Sample:

Nlr family card domain-containing protein 4 (Protein from Mus musculus)
Nlr family, apoptosis inhibitory protein 2 (Protein from Mus musculus)
Naip2/nlrc4 inflammasome, 11-fold disk (1 MDa, Sample)

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