Cryo-EM Structure of Human Ninjurin1 curved oligomer
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8uip
Q-score: 0.046
David L, Borges JP, Hollingsworth LR, Volchuk A, Jansen I, Garlick E, Steinberg BE, Wu H
Cell (2024) 187 pp. 2224-2235.e16 [ Pubmed: 38614101 DOI: doi:10.1016/j.cell.2024.03.008 ]
- Ninjurin-1 (16 kDa, Protein from Homo sapiens)
- Ninjurin 1 ring oligomer (Complex from Homo sapiens)
Cryo-EM structure of the unliganded form of NLR family apoptosis inhibitory protein 5 (NAIP5)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7rav
Q-score: 0.347
Paidimuddala B, Cao J, Nash G, Xie Q, Wu H, Zhang L
Nat Struct Mol Biol (2023) 30 pp. 159-166 [ Pubmed: 36604500 DOI: doi:10.1038/s41594-022-00889-2 ]
- Baculoviral iap repeat-containing protein 1e (161 kDa, Protein from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Pre-liganded form of naip5 (Cell from Mus musculus)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7jkq
Q-score: 0.434
Sharif H, Hollingsworth LR, Griswold AR, Hsiao JC, Wang Q, Bachovchin DA, Wu H
Immunity (2021) 54 pp. 1392- [ DOI: doi:10.1016/j.immuni.2021.04.024 Pubmed: 34019797 ]
- Dpp9-card8 complex (Complex from Homo sapiens)
- Dipeptidyl peptidase 9 (98 kDa, Protein from Homo sapiens)
- Caspase recruitment domain-containing protein 8 (60 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7jn7
Q-score: 0.403
Sharif H, Hollingsworth LR, Griswold AR, Hsiao JC, Wang Q, Bachovchin DA, Wu H
Immunity (2021) 54 pp. 1392- [ DOI: doi:10.1016/j.immuni.2021.04.024 Pubmed: 34019797 ]
- Dpp9-card8 complex (Complex from Homo sapiens)
- [(2~{r})-1-[(2~{r})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid (214 Da, Ligand)
- Dipeptidyl peptidase 9 (101 kDa, Protein from Homo sapiens)
- Caspase recruitment domain-containing protein 8 (60 kDa, Protein from Homo sapiens)
Cryo-EM structure of NLRP1-DPP9 complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6x6a
Q-score: 0.42
Hollingsworth LR, Sharif H, Griswold AR, Fontana P, Mintseris J, Dagbay KB, Paulo JA, Gygi SP, Bachovchin DA, Wu H
Nature (2021) 592 pp. 778-783 [ DOI: doi:10.1038/s41586-021-03350-4 Pubmed: 33731932 ]
- Nacht, lrr and pyd domains-containing protein 1 (29 kDa, Protein from Homo sapiens)
- Nacht, lrr and pyd domains-containing protein 1 (136 kDa, Protein from Homo sapiens)
- Dipeptidyl peptidase 9 (98 kDa, Protein from Homo sapiens)
- Dpp9-nlrp1 complex (Complex from Homo sapiens)
Cryo-EM structure of NLRP1-DPP9-VbP complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6x6c
Q-score: 0.489
Hollingsworth LR, Sharif H, Griswold AR, Fontana P, Mintseris J, Dagbay KB, Paulo JA, Gygi SP, Bachovchin DA, Wu H
Nature (2021) 592 pp. 778-783 [ DOI: doi:10.1038/s41586-021-03350-4 Pubmed: 33731932 ]
- Nacht, lrr and pyd domains-containing protein 1 (166 kDa, Protein from Homo sapiens)
- Dipeptidyl peptidase 9 (101 kDa, Protein from Homo sapiens)
- [(2~{r})-1-[(2~{r})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid (214 Da, Ligand)
- Dpp9-nlrp1 complex (Complex from Homo sapiens)
Cryo-EM structure of ASC-Caspase1 Octamer
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 7keu
Q-score: 0.301
Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H
Nat Commun (2021) 12 pp. 189-189 [ DOI: doi:10.1038/s41467-020-20320-y Pubmed: 33420033 ]
- Cryo-em structure of asc-caspase1 octamer (86 kDa, Complex from Homo sapiens)
Cryo-EM structure of CARD8-CARD filament
Resolution: 3.54 Å
EM Method: Helical reconstruction
Fitted PDBs: 6xkj
Q-score: 0.517
Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H
Nat Commun (2021) 12 pp. 189-189 [ DOI: doi:10.1038/s41467-020-20320-y Pubmed: 33420033 ]
- Caspase recruitment domain-containing protein 8 (10 kDa, Protein from Homo sapiens)
- Card8-card filament (Complex from Homo sapiens)
Cryo-EM structure of the NLRP1-CARD filament
Resolution: 3.72 Å
EM Method: Helical reconstruction
Fitted PDBs: 6xkk
Q-score: 0.324
Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H
Nat Commun (2021) 12 pp. 189-189 [ DOI: doi:10.1038/s41467-020-20320-y Pubmed: 33420033 ]
- Nacht, lrr and pyd domains-containing protein 1 (11 kDa, Protein from Homo sapiens)
- Nlrp1-card filament (Complex from Homo sapiens)
The Vo region of human V-ATPase in state 1 (focused refinement)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6wlw
Q-score: 0.579
Wang L, Wu D, Robinson CV, Wu H, Fu TM
Mol Cell (2020) 80 pp. 501- [ Pubmed: 33065002 DOI: doi:10.1016/j.molcel.2020.09.029 ]
- V-type proton atpase subunit d 1 (40 kDa, Protein from Homo sapiens)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Homo sapiens)
- (2~{s})-2-$l^{4}-azanyl-3-[[(2~{r})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid (497 Da, Ligand)
- Renin receptor (39 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit s1 (52 kDa, Protein from Homo sapiens)
- Ribonuclease kappa (15 kDa, Protein from Homo sapiens)
- Methyl (3r,6z,10e,14e)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphate (534 Da, Ligand)
- Human v-atpase with sidk (Complex from Homo sapiens)
- V-type proton atpase 21 kda proteolipid subunit (21 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit e 1 (9 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- 1,2-dicaproyl-sn-phosphatidyl-l-serine (455 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- V-type proton atpase 116 kda subunit a isoform 1 (96 kDa, Protein from Homo sapiens)
- Tri(methyl)-[2-[[(2~{r})-2-[(~{z})-octadec-9-enoyl]oxy-3-[(~{e})-1-oxidanylideneoctadec-9-enoxy]propoxy]-oxidanyl-phosphoryl]oxyethyl]azanium (787 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)