CryoEM structure of a 2,3-hydroxycinnamic acid 1,2-dioxygenase MhpB in substrate bound form
Dong X, Xu M, Wu M, Wang Y, Cheng X, Jiang W, Zheng D, Omar AH, Cheng Y, Li A, Ma L, Xing Q
J Hazard Mater (2025) 488 pp. 137431-137431 [ Pubmed: 39892151 DOI: doi:10.1016/j.jhazmat.2025.137431 ]
- Fe (ii) ion (55 Da, Ligand)
- The decamer complex of mhpb bound with its substrate (Complex from Escherichia coli K-12)
- 3-[2,3-bis(oxidanyl)phenyl]propanoic acid (182 Da, Ligand)
- 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase (34 kDa, Protein from Escherichia coli K-12)
CryoEM structure of the transketolase ANIP from Streptomyces hygrospinosus
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 8k03
Q-score: 0.422
Jiang WX, Cheng XQ, Wu M, Ma LX, Xing Q
To Be Published
- Putative transketolase (62 kDa, Protein from Streptomyces hygrospinosus)
- Dimer of the transketolase anip (Complex from Salmonella)
CryoEM structure of the Salmonella effector inositol phosphate phosphatase SopB
CryoEM structure of 3-phenylpropionate/cinnamic acid dioxygenase HcaE-HcaF complex
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8k0a
Q-score: 0.518
Jiang WX, Cheng XQ, Wu M, Ma LX, Xing Q
To Be Published
- Homohexamer of inositol phosphate phosphatase sopb (Complex from Escherichia coli (strain K12))
- 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha (51 kDa, Protein from Escherichia coli K-12)
- 3-phenylpropionate/cinnamic acid dioxygenase subunit beta (20 kDa, Protein from Escherichia coli K-12)
Cryo-EM structure of LKB1-STRADalpha-MO25alpha heterocomplex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8vsu
Q-score: 0.575
Chan LM, Courteau BJ, Maker A, Wu M, Basanta B, Mehmood H, Bulkley D, Joyce D, Lee BC, Mick S, Czarnik C, Gulati S, Lander GC, Verba KA
J Struct Biol (2024) 216 pp. 108108-108108 [ Pubmed: 38944401 DOI: doi:10.1016/j.jsb.2024.108108 ]
- Serine/threonine-protein kinase stk11 (50 kDa, Protein from Homo sapiens)
- Heterotrimeric complex of serine/threonine kinase lkb1 with psuedokinase strada and scaffolding mo25a (140 kDa, Complex from Homo sapiens)
- Isoform 3 of ste20-related kinase adapter protein alpha (47 kDa, Protein from Homo sapiens)
- Calcium-binding protein 39 (41 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Apoferritin at 100 keV on Alpine detector with a side-entry cryoholder
Chan LM, Courteau BJ, Maker A, Wu M, Basanta B, Mehmood H, Bulkley D, Joyce D, Lee BC, Mick S, Czarnik C, Gulati S, Lander GC, Verba KA
J Struct Biol (2024) 216 pp. 108108-108108 [ Pubmed: 38944401 DOI: doi:10.1016/j.jsb.2024.108108 ]
- Heavy chain apoferritin from mouse (487 kDa, Complex from Mus musculus)
- Heavy chain apoferritin from mouse (Protein from Mus musculus)
Aldolase at 100 keV on the Alpine detector with a side-entry cryoholder
Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ve1
Q-score: 0.607
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ Pubmed: 39843982 DOI: doi:10.1038/s41594-024-01472-7 ]
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (56 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)