Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode I)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jcu
Q-score: 0.401
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ Pubmed: 37286794 DOI: doi:10.1038/s41422-023-00830-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Mglu2-3 heterodimer in presence of ly341495 (Complex from Homo sapiens)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jcy
Q-score: 0.443
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ Pubmed: 37286794 DOI: doi:10.1038/s41422-023-00830-2 ]
- Mglu2-3 heterodimer in presence of ly341495, nam563, and ly2389575 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
Cryo-EM structure of G protein-free mGlu2-mGlu3 heterodimer in Acc state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jd2
Q-score: 0.479
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ Pubmed: 37286794 DOI: doi:10.1038/s41422-023-00830-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Mglu2-3 heterodimer in presence of glutamate, jnj-40411813, and cacl2 (Complex from Homo sapiens)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
Cryo-EM structure of G protein-free mGlu2-mGlu4 heterodimer in Acc state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jd4
Q-score: 0.456
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ Pubmed: 37286794 DOI: doi:10.1038/s41422-023-00830-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 4,serine/threonine-protein kinase mtor (114 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Mglu2-mglu4 heterodimer in presence of glutamate, jnj-40411813, and adx88178 (Complex from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with Gi1
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7xbw
Q-score: 0.468
Lu M, Zhao W, Han S, Lin X, Xu T, Tan Q, Wang M, Yi C, Chu X, Yang W, Zhu Y, Wu B, Zhao Q
Sci Adv (2022) 8 pp. eabn8048-eabn8048 [ DOI: doi:10.1126/sciadv.abn8048 Pubmed: 35767622 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Chemokine receptor cx3cr1 in complex with gi1 (Complex from Homo sapiens)
- Cx3c chemokine receptor 1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7jvp
Q-score: 0.485
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE
Cell (2021) 184 pp. 931-942.e18 [ DOI: doi:10.1016/j.cell.2021.01.027 Pubmed: 33571431 ]
- Skf-81297-bound dopamine receptor 1 in complex with gi protein (Complex from Homo sapiens)
- D(1a) dopamine receptor (55 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- (1r)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (317 Da, Ligand)
- Nanobody 35 (14 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Cryo-EM structure of Bromocriptine-bound dopamine receptor 2 in complex with Gi protein
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7jvr
Q-score: 0.407
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE
Cell (2021) 184 pp. 931-942.e18 [ DOI: doi:10.1016/j.cell.2021.01.027 Pubmed: 33571431 ]
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
- Bromocriptin-bound dopamine receptor 2 in complex with gi protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Bromoergocryptine (654 Da, Ligand)
- Soluble cytochrome b562,d(2) dopamine receptor (67 kDa, Protein from Homo sapiens)