Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 9ikm
Q-score: 0.422
Cryo-EM Structure of GCN2 HRSL Domain
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 9bf3
Q-score: 0.517
Solorio-Kirpichyan KM, Golovenko D, Xiao F, Yan N, Korostelev AA, Korennykh AV
To Be Published
- Gcn2 hrsl domain (116 kDa, Complex from Kluyveromyces marxianus)
- Non-specific serine/threonine protein kinase (190 kDa, Protein from Kluyveromyces marxianus)
Resolution: 3.22 Å
EM Method: Helical reconstruction
Fitted PDBs: 9ikj
Q-score: 0.53
Wang T, Li Z, Xu K, Huang W, Huang G, Zhang QC, Yan N
PNAS (2024) 121 pp. e2417046121-e2417046121 [ Pubmed: 39382995 DOI: doi:10.1073/pnas.2417046121 ]
- Tlp-1 (25 kDa, Protein from algae metagenome)
- Tlp-1a (Complex from algae metagenome)
Resolution: 3.51 Å
EM Method: Helical reconstruction
Fitted PDBs: 9ikk
Q-score: 0.452
Wang T, Li Z, Xu K, Huang W, Huang G, Zhang QC, Yan N
PNAS (2024) 121 pp. e2417046121-e2417046121 [ Pubmed: 39382995 DOI: doi:10.1073/pnas.2417046121 ]
- Tlp-2 (25 kDa, Protein from algae metagenome)
- Tlp-1b (Complex from algae metagenome)
mycobacterial efflux pump, apo state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k1m
Q-score: 0.574
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ Pubmed: 39226350 DOI: doi:10.1073/pnas.2403421121 ]
- Multidrug efflux system atp-binding protein rv1218c (31 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Cardiolipin (1 kDa, Ligand)
- (1s)-2-{[(s)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (746 Da, Ligand)
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
mycobacterial efflux pump, substrate-bound state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1n
Q-score: 0.541
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ Pubmed: 39226350 DOI: doi:10.1073/pnas.2403421121 ]
- Cardiolipin (1 kDa, Ligand)
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Rifampicin (822 Da, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
mycobacterial efflux pump, AMPPNP bound state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k1o
Q-score: 0.597
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ Pubmed: 39226350 DOI: doi:10.1073/pnas.2403421121 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Magnesium ion (24 Da, Ligand)
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
Cryo-EM structure of apo state human Cav3.2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayg
Q-score: 0.537
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
Cryo-EM structure of human Cav3.2 with TTA-A2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9ayh
Q-score: 0.52
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- 2-(4-cyclopropylphenyl)-n-{(1r)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide (378 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
Cryo-EM structure of human Cav3.2 with TTA-P2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9ayj
Q-score: 0.484
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 3,5-dichloro-n-[(1-{[(4s)-2,2-dimethyloxan-4-yl]methyl}-4-fluoropiperidin-4-yl)methyl]benzamide (431 Da, Ligand)