Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6a90
Q-score: 0.56
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Sodium ion (22 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- Dc1a (Complex from Diguetia canities)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana and dc1a (200 kDa, Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6a91
Q-score: 0.515
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Water (18 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- Dc1a (Complex from Diguetia canities)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound with saxitoxin and dc1a (200 kDa, Complex)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6a95
Q-score: 0.565
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Sodium ion (22 Da, Ligand)
- Water (18 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- (1r,5r,6r,7r,9s,11s,12s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name) (319 Da, Ligand)
- Dc1a (Complex from Diguetia canities)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound with saxitoxin and dc1a (200 kDa, Complex)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6agf
Q-score: 0.526
Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N
Science (2018) 362 [ Pubmed: 30190309 DOI: doi:10.1126/science.aau2486 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Complex of human sodium channel protein type 4 subunit alpha and human sodium channel subunit beta-1 (200 kDa, Complex)
- Sodium channel protein type 4 subunit alpha (212 kDa, Protein from Homo sapiens)
- Human sodium channel protein type 4 subunit alpha (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human sodium channel subunit beta-1 (Complex from Homo sapiens)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Cryo-EM map of the rabbit voltage-gated calcium channel Cav1.1 at 3.6 angstrom resolution
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5gjv
Q-score: 0.385
Wu JP, Yan Z, Li ZQ, Qian XY, Lu S, Dong MQ, Zhou Q, Yan N
Nature (2016) 537 pp. 191-196 [ Pubmed: 27580036 DOI: doi:10.1038/nature19321 ]
- Voltage-dependent l-type calcium channel subunit beta-1 (11 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-1 (22 kDa, Protein from Oryctolagus cuniculus)
- Voltage-gated calcium channel cav1.1 (500 kDa, Complex from Oryctolagus cuniculus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
ClassIa map of the rabbit voltage-gated calcium channel Cav1.1
Wu JP, Yan Z, Li ZQ, Qian XY, Lu S, Dong MQ, Zhou Q, Yan N
Nature (2016) 537 pp. 191-196 [ Pubmed: 27580036 DOI: doi:10.1038/nature19321 ]
- Voltage-gated calcium channel cav1.1 (500 kDa, Complex from Oryctolagus cuniculus)
ClassII map of the rabbit voltage-gated calcium channel Cav1.1
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 5gjw
Q-score: 0.36
Wu JP, Yan Z, Li ZQ, Qian XY, Lu S, Dong MQ, Zhou Q, Yan N
Nature (2016) 537 pp. 191-196 [ Pubmed: 27580036 DOI: doi:10.1038/nature19321 ]
- Voltage-gated calcium channel cav1.1 (500 kDa, Complex from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit beta-1 (11 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit beta-1 (22 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
Cryo-EM map of RyR1 in a closed state (C1 conformer)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 5gky
Q-score: 0.317
Bai XC, Yan Z, Wu JP, Li ZQ, Yan N
Cell Res (2016) 26 pp. 995-1006 [ DOI: doi:10.1038/cr.2016.89 Pubmed: 27468892 ]
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Fkbp12 (Complex from Oryctolagus cuniculus)
- Ryr1 in complex with fkbp12 (2 MDa, Complex)
- Ryr1 (Complex from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
Cryo-EM map of RyR1 in a closed state (C3 conformer)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 5gkz
Q-score: 0.337
Bai XC, Yan Z, Wu JP, Li ZQ, Yan N
Cell Res (2016) 26 pp. 995-1006 [ Pubmed: 27468892 DOI: doi:10.1038/cr.2016.89 ]
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Fkbp12 (Complex from Oryctolagus cuniculus)
- Ryr1 in complex with fkbp12 (2 MDa, Complex)
- Ryr1 (Complex from Oryctolagus cuniculus)
Cryo-EM map of RyR1 in a closed state (C4 conformer)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 5gl0
Q-score: 0.309
Bai XC, Yan Z, Wu JP, Li ZQ, Yan N
Cell Res (2016) 26 pp. 995-1006 [ DOI: doi:10.1038/cr.2016.89 Pubmed: 27468892 ]
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Fkbp12 (Complex from Oryctolagus cuniculus)
- Ryr1 in complex with fkbp12 (2 MDa, Complex)
- Ryr1 (Complex from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)