Molecular basis for pore blockade of human Sodium channel Nav1.2 by mu-conotoxin KIIIA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6j8e
Q-score: 0.477
Pan X, Li Z, Huang X, Huang G, Gao S, Shen H, Liu L, Lei J, Yan N
Science (2019) 363 pp. 1309-1313 [ DOI: doi:10.1126/science.aaw2999 Pubmed: 30765605 ]
- Human voltage gated sodium channel sub-type 1.2 (Protein from Homo sapiens)
- Nav1.2-beta2 (Complex from Homo sapiens)
- Mu-conotoxin kiiia (Protein from Conus kinoshitai)
- Sodium channel protein type 2 subunit alpha (Protein from Homo sapiens)
- Nav1.2-beta2-kiiia (252 MDa, Complex)
- Kiiia (Complex from Conus kinoshitai)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6j8g, 6j8h
Q-score: 0.495
Shen H, Liu D, Wu K, Lei J, Yan N
Science (2019) 363 pp. 1303-1308 [ Pubmed: 30765606 DOI: doi:10.1126/science.aaw2493 ]
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Complex of human voltage-gated sodium channel nav1.7 with auxiliary beta subunits, huwentoxin-iv and saxitoxin (Complex from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6j8i, 6j8j
Q-score: 0.46
Shen H, Liu D, Wu K, Lei J, Yan N
Science (2019) 363 pp. 1303-1308 [ Pubmed: 30765606 DOI: doi:10.1126/science.aaw2493 ]
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- (1r,5r,6r,7r,9s,11s,12s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name) (319 Da, Ligand)
- Complex of human voltage-gated sodium channel nav1.7 with auxiliary beta subunits, protx-ii and tetrodotoxin (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6a90
Q-score: 0.56
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Sodium ion (22 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- Dc1a (Complex from Diguetia canities)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana and dc1a (200 kDa, Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6a91
Q-score: 0.515
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Water (18 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- Dc1a (Complex from Diguetia canities)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound with saxitoxin and dc1a (200 kDa, Complex)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6a95
Q-score: 0.565
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Sodium ion (22 Da, Ligand)
- Water (18 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- (1r,5r,6r,7r,9s,11s,12s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name) (319 Da, Ligand)
- Dc1a (Complex from Diguetia canities)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound with saxitoxin and dc1a (200 kDa, Complex)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6agf
Q-score: 0.526
Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N
Science (2018) 362 [ Pubmed: 30190309 DOI: doi:10.1126/science.aau2486 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Complex of human sodium channel protein type 4 subunit alpha and human sodium channel subunit beta-1 (200 kDa, Complex)
- Sodium channel protein type 4 subunit alpha (212 kDa, Protein from Homo sapiens)
- Human sodium channel protein type 4 subunit alpha (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human sodium channel subunit beta-1 (Complex from Homo sapiens)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 5x0m
Q-score: 0.262