cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6m49
Q-score: 0.335
Yan R, Cao P, Song W, Qian H, Du X, Coates HW, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown AJ, Zhou Q, Yan C, Yan N
Science (2021) 371 [ Pubmed: 33446483 DOI: doi:10.1126/science.abb2224 ]
- Sterol regulatory element-binding protein cleavage-activating protein,sterol regulatory element-binding protein cleavage-activating protein (63 kDa, Protein from Homo sapiens)
- 25-hydroxycholesterol (402 Da, Ligand)
- Insulin-induced gene 2 protein (24 kDa, Protein from Homo sapiens)
- Scap and insig complex (Complex from Homo sapiens)
Molecular basis for pore blockade of human Sodium channel Nav1.2 by mu-conotoxin KIIIA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6j8e
Q-score: 0.477
Pan X, Li Z, Huang X, Huang G, Gao S, Shen H, Liu L, Lei J, Yan N
Science (2019) 363 pp. 1309-1313 [ DOI: doi:10.1126/science.aaw2999 Pubmed: 30765605 ]
- Human voltage gated sodium channel sub-type 1.2 (Protein from Homo sapiens)
- Nav1.2-beta2 (Complex from Homo sapiens)
- Mu-conotoxin kiiia (Protein from Conus kinoshitai)
- Sodium channel protein type 2 subunit alpha (Protein from Homo sapiens)
- Nav1.2-beta2-kiiia (252 MDa, Complex)
- Kiiia (Complex from Conus kinoshitai)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6j8g, 6j8h
Q-score: 0.495
Shen H, Liu D, Wu K, Lei J, Yan N
Science (2019) 363 pp. 1303-1308 [ Pubmed: 30765606 DOI: doi:10.1126/science.aaw2493 ]
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Complex of human voltage-gated sodium channel nav1.7 with auxiliary beta subunits, huwentoxin-iv and saxitoxin (Complex from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6j8i, 6j8j
Q-score: 0.46
Shen H, Liu D, Wu K, Lei J, Yan N
Science (2019) 363 pp. 1303-1308 [ Pubmed: 30765606 DOI: doi:10.1126/science.aaw2493 ]
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- (1r,5r,6r,7r,9s,11s,12s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name) (319 Da, Ligand)
- Complex of human voltage-gated sodium channel nav1.7 with auxiliary beta subunits, protx-ii and tetrodotoxin (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
Cryo-EM structure of a P-type ATPase
Resolution: 4.11 Å
EM Method: Single-particle
Fitted PDBs: 6a69
Q-score: 0.386
Gong D, Chi X, Ren K, Huang G, Zhou G, Yan N, Lei J, Zhou Q
Nat Commun (2018) 9 pp. 3623-3623 [ DOI: doi:10.1038/s41467-018-06075-7 Pubmed: 30190470 ]
- Neuroplastin (31 kDa, Protein from Homo sapiens)
- Complex of one pmca1 molecular with one nptn molecular (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Plasma membrane calcium-transporting atpase 1 (140 kDa, Protein from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6a90
Q-score: 0.56
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Sodium ion (22 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- Dc1a (Complex from Diguetia canities)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana and dc1a (200 kDa, Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6a91
Q-score: 0.515
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Water (18 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- Dc1a (Complex from Diguetia canities)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound with saxitoxin and dc1a (200 kDa, Complex)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6a95
Q-score: 0.565
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Sodium ion (22 Da, Ligand)
- Water (18 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- (1r,5r,6r,7r,9s,11s,12s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name) (319 Da, Ligand)
- Dc1a (Complex from Diguetia canities)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound with saxitoxin and dc1a (200 kDa, Complex)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6agf
Q-score: 0.526
Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N
Science (2018) 362 [ Pubmed: 30190309 DOI: doi:10.1126/science.aau2486 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Complex of human sodium channel protein type 4 subunit alpha and human sodium channel subunit beta-1 (200 kDa, Complex)
- Sodium channel protein type 4 subunit alpha (212 kDa, Protein from Homo sapiens)
- Human sodium channel protein type 4 subunit alpha (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human sodium channel subunit beta-1 (Complex from Homo sapiens)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Cryo-EM structure of human Ptch1
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6dmb
Q-score: 0.408
Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei J, Yan N
Science (2018) 361 [ Pubmed: 29954986 DOI: doi:10.1126/science.aas8935 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Patch1 (Cellular component from Homo sapiens)
- Protein patched homolog 1 (150 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)