voltage-gated sodium channel Nav1.5 with quinidine
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6lqa
Q-score: 0.438
Li Z, Jin X, Wu T, Huang G, Wu K, Lei J, Pan X, Yan N
Angew Chem Int Ed Engl (2021) 60 pp. 11474-11480 [ Pubmed: 33684260 DOI: doi:10.1002/anie.202102196 ]
- Quinidine (324 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 5 subunit alpha (231 kDa, Protein from Homo sapiens)
- Voltage-gated sodium channel with drug (Complex from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7jpk
Q-score: 0.55
Angew Chem Int Ed Engl (2021) 60 pp. 3131-3137 [ Pubmed: 33125829 DOI: doi:10.1002/anie.202011793 ]
- Rcav1.1-100s (Complex from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
- Methyl (4~{s})-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate (356 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7jpl
Q-score: 0.53
Angew Chem Int Ed Engl (2021) 60 pp. 3131-3137 [ Pubmed: 33125829 DOI: doi:10.1002/anie.202011793 ]
- Calcium ion (40 Da, Ligand)
- Rcav1.1-10s (Complex from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
- Methyl (4~{s})-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate (356 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7jpv
Q-score: 0.507
Angew Chem Int Ed Engl (2021) 60 pp. 3131-3137 [ Pubmed: 33125829 DOI: doi:10.1002/anie.202011793 ]
- Calcium ion (40 Da, Ligand)
- Rcav1.1-1s (Complex from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7jpw
Q-score: 0.543
Angew Chem Int Ed Engl (2021) 60 pp. 3131-3137 [ Pubmed: 33125829 DOI: doi:10.1002/anie.202011793 ]
- Rcav1.1-100r (Complex from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Methyl (4~{r})-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate (357 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
Rabbit Cav1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 Angstrom resolution
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7jpx
Q-score: 0.563
Angew Chem Int Ed Engl (2021) 60 pp. 3131-3137 [ DOI: doi:10.1002/anie.202011793 Pubmed: 33125829 ]
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
- Amlodipine (408 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Rcav1.1-100a (Complex from Oryctolagus cuniculus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)