Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7mix
Q-score: 0.496
Nature (2021) 596 pp. 143-147 [ Pubmed: 34234349 DOI: doi:10.1038/s41586-021-03699-6 ]
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Cav2.2 (Complex from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Omega-conotoxin mviia (2 kDa, Protein from Conus magus)
- Voltage-dependent n-type calcium channel subunit alpha-1b (262 kDa, Protein from Homo sapiens)
- Cav2.2-ziconotide (Complex from Homo sapiens)
Human N-type voltage-gated calcium channel Cav2.2 at 3.1 Angstrom resolution
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7miy
Q-score: 0.472
Nature (2021) 596 pp. 143-147 [ Pubmed: 34234349 DOI: doi:10.1038/s41586-021-03699-6 ]
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Cav2.2 (Complex from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent n-type calcium channel subunit alpha-1b (262 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6p2j
Q-score: 0.453
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N
Nature (2020) 581 pp. 333-338 [ DOI: doi:10.1038/s41586-020-2290-0 Pubmed: 32433614 ]
- Sterol o-acyltransferase 1 (69 kDa, Protein from Homo sapiens)
- Acat1 (Complex from Homo sapiens)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6p2p
Q-score: 0.462
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N
Nature (2020) 581 pp. 333-338 [ DOI: doi:10.1038/s41586-020-2290-0 Pubmed: 32433614 ]
- Sterol o-acyltransferase 1 (69 kDa, Protein from Homo sapiens)
- Acat1 (Complex from Homo sapiens)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6vp0
Q-score: 0.514
Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M
Nature (2020) 581 pp. 329-332 [ DOI: doi:10.1038/s41586-020-2280-2 Pubmed: 32433610 ]
- Diacylglycerol o-acyltransferase 1 (55 kDa, Protein from Homo sapiens)
- Human diacylglycerol acyltransferase 1 in complex with oleoyl-coa (Complex from Homo sapiens)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6kzo
Q-score: 0.508
Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, Pan X, Yan N
Nature (2019) 576 pp. 492-497 [ DOI: doi:10.1038/s41586-019-1801-3 Pubmed: 31766050 ]
- Membrane protein (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1g (250 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6kzp
Q-score: 0.548
Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, Pan X, Yan N
Nature (2019) 576 pp. 492-497 [ Pubmed: 31766050 DOI: doi:10.1038/s41586-019-1801-3 ]
- Voltage-dependent t-type calcium channel subunit alpha-1g,voltage-dependent t-type calcium channel subunit alpha-1g (238 kDa, Protein from Homo sapiens)
- ~{n}-[[1-[2-(~{tert}-butylamino)-2-oxidanylidene-ethyl]piperidin-4-yl]methyl]-3-chloranyl-5-fluoranyl-benzamide (383 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Membrane protein-ligand (Complex from Homo sapiens)
Structure of RyR2 (F/A/C/Ca2+ dataset)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6ji0
Q-score: 0.322
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ DOI: doi:10.1038/s41586-019-1377-y Pubmed: 31278385 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ryr2 in complex with fkbp12.6 (Complex from Sus scrofa)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Ryr2 (564 kDa, Protein from Sus scrofa)
Structure of RyR2 (F/apoCaM dataset)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6ji8
Q-score: 0.384
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ryr2 in complex with fkbp12.6 and apo-calmodulin (Complex from Sus scrofa)
- Ryr2 (564 kDa, Protein from Sus scrofa)
Structure of RyR2 (F/A/C/L-Ca2+/apo-CaM-M dataset)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6jii
Q-score: 0.319
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr2 (564 kDa, Protein from Sus scrofa)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Ryr2 in complex with fkbp12.6 and apo-calmodulin-mimicking mutant (Complex from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)