Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6vp0
Q-score: 0.514
Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M
Nature (2020) 581 pp. 329-332 [ DOI: doi:10.1038/s41586-020-2280-2 Pubmed: 32433610 ]
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Diacylglycerol o-acyltransferase 1 (55 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Human diacylglycerol acyltransferase 1 in complex with oleoyl-coa (Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6kzo
Q-score: 0.508
Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, Pan X, Yan N
Nature (2019) 576 pp. 492-497 [ Pubmed: 31766050 DOI: doi:10.1038/s41586-019-1801-3 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Membrane protein (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1g (250 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6kzp
Q-score: 0.548
Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, Pan X, Yan N
Nature (2019) 576 pp. 492-497 [ Pubmed: 31766050 DOI: doi:10.1038/s41586-019-1801-3 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1g,voltage-dependent t-type calcium channel subunit alpha-1g (238 kDa, Protein from Homo sapiens)
- ~{n}-[[1-[2-(~{tert}-butylamino)-2-oxidanylidene-ethyl]piperidin-4-yl]methyl]-3-chloranyl-5-fluoranyl-benzamide (383 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Membrane protein-ligand (Complex from Homo sapiens)
Single-particle electron cryo-microscopy structure of ryanodine receptor RyR1 in complex with FKBP12
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 3j8h
Q-score: 0.338
Yan Z, Bai XC, Yan C, Wu J, Li Z, Xie T, Peng W, Yin CC, Li X, Scheres SH, Shi Y, Yan N
Nature (2015) 517 pp. 50-55 [ Pubmed: 25517095 DOI: doi:10.1038/nature14063 ]
- Ryanodine receptor ryr1 (5 MDa, Protein from Oryctolagus cuniculus)
- Rabbit ryr1 in complex with its modulator fkbp12 (5 MDa, Sample)