Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6w5r
Q-score: 0.417
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ Pubmed: 32544384 DOI: doi:10.1016/j.cell.2020.05.020 ]
- Npc1 nanodisc (150 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)
NPC1 structure in GDN micelles at pH 8.0
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6w5s
Q-score: 0.541
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ Pubmed: 32544384 DOI: doi:10.1016/j.cell.2020.05.020 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Npc1 at ph 8.0 (150 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
NPC1 structure in GDN micelles at pH 5.5, conformation a
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6w5t
Q-score: 0.421
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ Pubmed: 32544384 DOI: doi:10.1016/j.cell.2020.05.020 ]
- Cholesterol (386 Da, Ligand)
- Npc1 in gdn micelles at ph 5.5 (150 kDa, Complex from Homo sapiens)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
NPC1 structure in GDN micelles at pH 5.5, conformation b
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6w5u
Q-score: 0.405
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ Pubmed: 32544384 DOI: doi:10.1016/j.cell.2020.05.020 ]
- Cholesterol (386 Da, Ligand)
- Npc1 in gdn micelles at ph 5.5 (150 kDa, Complex from Homo sapiens)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
NPC1-NPC2 complex structure at pH 5.5
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6w5v
Q-score: 0.358
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ Pubmed: 32544384 DOI: doi:10.1016/j.cell.2020.05.020 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Npc intracellular cholesterol transporter 2 (17 kDa, Protein from Homo sapiens)
- Npc1-npc2 complex at ph 5.5 (170 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6p2j
Q-score: 0.453
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N
Nature (2020) 581 pp. 333-338 [ Pubmed: 32433614 DOI: doi:10.1038/s41586-020-2290-0 ]
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Acat1 (Complex from Homo sapiens)
- Sterol o-acyltransferase 1 (69 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6p2p
Q-score: 0.462
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N
Nature (2020) 581 pp. 333-338 [ Pubmed: 32433614 DOI: doi:10.1038/s41586-020-2290-0 ]
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Acat1 (Complex from Homo sapiens)
- Sterol o-acyltransferase 1 (69 kDa, Protein from Homo sapiens)
Cryo EM structure of human SEIPIN
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6ds5
Q-score: 0.473
Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, Yang H
Dev Cell (2018) 47 pp. 248-256.e4 [ DOI: doi:10.1016/j.devcel.2018.09.010 Pubmed: 30293840 ]
- Seipin (Cellular component from Homo sapiens)
- Seipin (45 kDa, Protein from Homo sapiens)
Cryo-EM structure of human ABCA1
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 5xjy
Q-score: 0.387
Qian H, Zhao X, Cao P, Lei J, Yan N, Gong X
Cell (2017) 169 pp. 1228-1239.e10 [ DOI: doi:10.1016/j.cell.2017.05.020 Pubmed: 28602350 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Membrane protein (Cellular component from Homo sapiens)
- Atp-binding cassette sub-family a member 1 (259 kDa, Protein from Homo sapiens)