Cryo-EM structure of Scap/Insig complex in the present of digitonin.
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7etw
Q-score: 0.351
Yan R, Cao P, Song W, Li Y, Wang T, Qian H, Yan C, Yan N
Cell Rep (2021) 35 pp. 109299- [ DOI: doi:10.1016/j.celrep.2021.109299 ]
- Sterol regulatory element-binding protein cleavage-activating protein (81 kDa, Protein from Homo sapiens)
- Digitonin (1 kDa, Ligand)
- Insulin-induced gene 2 protein (24 kDa, Protein from Homo sapiens)
- Scap and insig complex (Complex from Homo sapiens)
NPC1-NPC2 complex structure at pH 5.5
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6w5v
Q-score: 0.358
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ DOI: doi:10.1016/j.cell.2020.05.020 Pubmed: 32544384 ]
- Npc intracellular cholesterol transporter 2 (17 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Npc1-npc2 complex at ph 5.5 (170 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)
Structure of RyR2 (F/P/Ca2+ dataset)
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 6jgz
Q-score: 0.249
Chi X, Gong D, Ren K, Zhou G, Huang G, Lei J, Zhou Q, Yan N
PNAS (2019) 116 pp. 25575-25582 [ Pubmed: 31792195 DOI: doi:10.1073/pnas.1914451116 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryr2 (564 kDa, Protein from Sus scrofa)
- Ryr2 in complex with fkbp12.6 (Complex from Sus scrofa)
- Zinc ion (65 Da, Ligand)
Structure of RyR2 (F/A/Ca2+ dataset)
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 6jh6
Q-score: 0.222
Chi X, Gong D, Ren K, Zhou G, Huang G, Lei J, Zhou Q, Yan N
PNAS (2019) 116 pp. 25575-25582 [ Pubmed: 31792195 DOI: doi:10.1073/pnas.1914451116 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr2 in complex with fkbp12.6 (Complex from Sus scrofa)
- Ryr2 (564 kDa, Protein from Sus scrofa)
Structure of RyR2 (F/C/Ca2+ dataset)
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6jhn
Q-score: 0.252
Chi X, Gong D, Ren K, Zhou G, Huang G, Lei J, Zhou Q, Yan N
PNAS (2019) 116 pp. 25575-25582 [ Pubmed: 31792195 DOI: doi:10.1073/pnas.1914451116 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ryr2 in complex with fkbp12.6 (Complex from Sus scrofa)
- Ryr2 (564 kDa, Protein from Sus scrofa)
- Caffeine (194 Da, Ligand)
Structure of RyR2 (F/A/C/Ca2+ dataset)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6ji0
Q-score: 0.322
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ DOI: doi:10.1038/s41586-019-1377-y Pubmed: 31278385 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ryr2 in complex with fkbp12.6 (Complex from Sus scrofa)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Ryr2 (564 kDa, Protein from Sus scrofa)
Structure of RyR2 (F/A/C/L-Ca2+/apo-CaM-M dataset)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6jii
Q-score: 0.319
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr2 (564 kDa, Protein from Sus scrofa)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Ryr2 in complex with fkbp12.6 and apo-calmodulin-mimicking mutant (Complex from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of RyR2 (F/A/C/L-Ca2+/Ca2+CaM dataset)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6jiu
Q-score: 0.303
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ryr2 in complex with fkbp12.6 and ca2+-loaded calmodulin at low ca2+ concentrations (Complex from Sus scrofa)
- Calcium ion (40 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr2 (564 kDa, Protein from Sus scrofa)
- Caffeine (194 Da, Ligand)
Structure of RyR2 (P/L-Ca2+/Ca2+-CaM dataset)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6jv2
Q-score: 0.267
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ryr2 in complex with calmodulin (Complex from Sus scrofa)
- Ryr2 (564 kDa, Protein from Sus scrofa)