Cryo-EM structure of Scap/Insig complex in the present of digitonin.
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7etw
Q-score: 0.351
Yan R, Cao P, Song W, Li Y, Wang T, Qian H, Yan C, Yan N
Cell Rep (2021) 35 pp. 109299- [ DOI: doi:10.1016/j.celrep.2021.109299 ]
- Sterol regulatory element-binding protein cleavage-activating protein (81 kDa, Protein from Homo sapiens)
- Scap and insig complex (Complex from Homo sapiens)
- Digitonin (1 kDa, Ligand)
- Insulin-induced gene 2 protein (24 kDa, Protein from Homo sapiens)
cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6m49
Q-score: 0.335
Yan R, Cao P, Song W, Qian H, Du X, Coates HW, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown AJ, Zhou Q, Yan C, Yan N
Science (2021) 371 [ Pubmed: 33446483 DOI: doi:10.1126/science.abb2224 ]
- 25-hydroxycholesterol (402 Da, Ligand)
- Scap and insig complex (Complex from Homo sapiens)
- Sterol regulatory element-binding protein cleavage-activating protein,sterol regulatory element-binding protein cleavage-activating protein (63 kDa, Protein from Homo sapiens)
- Insulin-induced gene 2 protein (24 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6p2j
Q-score: 0.453
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N
Nature (2020) 581 pp. 333-338 [ Pubmed: 32433614 DOI: doi:10.1038/s41586-020-2290-0 ]
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Acat1 (Complex from Homo sapiens)
- Sterol o-acyltransferase 1 (69 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6p2p
Q-score: 0.462
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N
Nature (2020) 581 pp. 333-338 [ Pubmed: 32433614 DOI: doi:10.1038/s41586-020-2290-0 ]
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Acat1 (Complex from Homo sapiens)
- Sterol o-acyltransferase 1 (69 kDa, Protein from Homo sapiens)
Cryo EM structure of human SEIPIN
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6ds5
Q-score: 0.473
Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, Yang H
Dev Cell (2018) 47 pp. 248-256.e4 [ DOI: doi:10.1016/j.devcel.2018.09.010 Pubmed: 30293840 ]
- Seipin (Cellular component from Homo sapiens)
- Seipin (45 kDa, Protein from Homo sapiens)