mycobacterial efflux pump, apo state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k1m
Q-score: 0.574
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ DOI: doi:10.1073/pnas.2403421121 Pubmed: 39226350 ]
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system atp-binding protein rv1218c (31 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- (1s)-2-{[(s)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (746 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
mycobacterial efflux pump, substrate-bound state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1n
Q-score: 0.541
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ DOI: doi:10.1073/pnas.2403421121 Pubmed: 39226350 ]
- Rifampicin (822 Da, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Cardiolipin (1 kDa, Ligand)
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
mycobacterial efflux pump, AMPPNP bound state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k1o
Q-score: 0.597
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ DOI: doi:10.1073/pnas.2403421121 Pubmed: 39226350 ]
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Magnesium ion (24 Da, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Cardiolipin (1 kDa, Ligand)
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8if8
Q-score: 0.552
Gong Y, Wei C, Wang J, Mu N, Lu Q, Wu C, Yan N, Yang H, Zhao Y, Yang X, Gurcha SS, Veerapen N, Batt SM, Hao Z, Da L, Besra GS, Rao Z, Zhang L
PNAS (2023) 120 pp. e2302858120-e2302858120 [ Pubmed: 37252995 DOI: doi:10.1073/pnas.2302858120 ]
- Afta dimer (69 kDa, Complex from Mycobacterium tuberculosis H37Rv)
- Galactan 5-o-arabinofuranosyltransferase (69 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Calcium ion (40 Da, Ligand)
cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6m49
Q-score: 0.335
Yan R, Cao P, Song W, Qian H, Du X, Coates HW, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown AJ, Zhou Q, Yan C, Yan N
Science (2021) 371 [ Pubmed: 33446483 DOI: doi:10.1126/science.abb2224 ]
- 25-hydroxycholesterol (402 Da, Ligand)
- Scap and insig complex (Complex from Homo sapiens)
- Sterol regulatory element-binding protein cleavage-activating protein,sterol regulatory element-binding protein cleavage-activating protein (63 kDa, Protein from Homo sapiens)
- Insulin-induced gene 2 protein (24 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6w5r
Q-score: 0.417
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ Pubmed: 32544384 DOI: doi:10.1016/j.cell.2020.05.020 ]
- Npc1 nanodisc (150 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)
NPC1 structure in GDN micelles at pH 8.0
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6w5s
Q-score: 0.541
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ Pubmed: 32544384 DOI: doi:10.1016/j.cell.2020.05.020 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Npc1 at ph 8.0 (150 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
NPC1 structure in GDN micelles at pH 5.5, conformation a
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6w5t
Q-score: 0.421
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ Pubmed: 32544384 DOI: doi:10.1016/j.cell.2020.05.020 ]
- Cholesterol (386 Da, Ligand)
- Npc1 in gdn micelles at ph 5.5 (150 kDa, Complex from Homo sapiens)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
NPC1 structure in GDN micelles at pH 5.5, conformation b
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6w5u
Q-score: 0.405
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ Pubmed: 32544384 DOI: doi:10.1016/j.cell.2020.05.020 ]
- Cholesterol (386 Da, Ligand)
- Npc1 in gdn micelles at ph 5.5 (150 kDa, Complex from Homo sapiens)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
NPC1-NPC2 complex structure at pH 5.5
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6w5v
Q-score: 0.358
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ Pubmed: 32544384 DOI: doi:10.1016/j.cell.2020.05.020 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Npc intracellular cholesterol transporter 2 (17 kDa, Protein from Homo sapiens)
- Npc1-npc2 complex at ph 5.5 (170 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)