Electron Microscopy Data Bank

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Release date: June 12, 2019
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6jp5
Q-score: 0.39

Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N

Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]

Sample:

Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Calcium ion (40 Da, Ligand)
1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (346 Da, Ligand)
Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Oryctolagus cuniculus)
Cav1.1-drug complex (Complex)
Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
Ethanolamine (61 Da, Ligand)
Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)

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EMD-9867

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Rabbit Cav1.1-Bay K8644 Complex

Release date: June 12, 2019
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6jp8
Q-score: 0.385

Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N

Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]

Sample:

Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Calcium ion (40 Da, Ligand)
Voltage-dependent calcium channel subunit alpha-2/delta-1 (118 kDa, Protein from Oryctolagus cuniculus)
Cav1.1-drug complex (Complex)
Methyl (4~{s})-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate (356 Da, Ligand)
Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
Ethanolamine (61 Da, Ligand)
Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)

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EMD-9868

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Rabbit Cav1.1-Verapamil Complex

Release date: June 12, 2019
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6jpa
Q-score: 0.4

Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N

Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]

Sample:

Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
Voltage-dependent l-type calcium channel subunit beta-1 (57 kDa, Protein from Oryctolagus cuniculus)
2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Calcium ion (40 Da, Ligand)
1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
Voltage-dependent calcium channel subunit alpha-2/delta-1 (118 kDa, Protein from Oryctolagus cuniculus)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
(3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
Cav1.1-drug complex (Complex)
(2s)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile (454 Da, Ligand)
Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
Ethanolamine (61 Da, Ligand)
Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
Voltage-dependent l-type calcium channel subunit alpha-1s (172 kDa, Protein from Oryctolagus cuniculus)

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EMD-9869

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Rabbit Cav1.1-Diltiazem Complex

Release date: June 12, 2019
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6jpb
Q-score: 0.397

Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N

Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]

Sample:

Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
Diltiazem (414 Da, Ligand)
2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Calcium ion (40 Da, Ligand)
1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Voltage-dependent calcium channel subunit alpha-2/delta-1 (118 kDa, Protein from Oryctolagus cuniculus)
Cav1.1-drug complex (Complex)
Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
Ethanolamine (61 Da, Ligand)
Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
Voltage-dependent l-type calcium channel subunit beta-1 (57 kDa, Protein from Oryctolagus cuniculus)

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EMD-6770

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Structure of the Nav1.4-beta1 complex from electric eel

Release date: Aug. 9, 2017
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 5xsy
Q-score: 0.403

Yan Z, Zhou Q, Wang L, Wu J, Zhao Y, Huang G, Peng W, Shen H, Lei J, Yan N

Cell (2017) 170 pp. 470-482.e11 [ Pubmed: 28735751 DOI: doi:10.1016/j.cell.2017.06.039 ]

Sample:

Sodium channel protein (208 kDa, Protein from Electrophorus electricus)
Voltage gated sodium channel eenav1.4 (Cellular component from Electrophorus electricus)
Voltage-gated sodium channel beta subunit 1 (23 kDa, Protein from Electrophorus electricus)

EMD-9513

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Cryo-EM map of the rabbit voltage-gated calcium channel Cav1.1 at 3.6 angstrom resolution

Release date: Sept. 14, 2016
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5gjv
Q-score: 0.385

Wu JP, Yan Z, Li ZQ, Qian XY, Lu S, Dong MQ, Zhou Q, Yan N

Nature (2016) 537 pp. 191-196 [ DOI: doi:10.1038/nature19321 Pubmed: 27580036 ]

Sample:

Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
Voltage-gated calcium channel cav1.1 (500 kDa, Complex from Oryctolagus cuniculus)
2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
Calcium ion (40 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Voltage-dependent l-type calcium channel subunit beta-1 (22 kDa, Protein from Oryctolagus cuniculus)
Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
Voltage-dependent l-type calcium channel subunit beta-1 (11 kDa, Protein from Oryctolagus cuniculus)

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EMD-9515

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ClassII map of the rabbit voltage-gated calcium channel Cav1.1

Release date: Sept. 14, 2016
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 5gjw
Q-score: 0.36

Wu JP, Yan Z, Li ZQ, Qian XY, Lu S, Dong MQ, Zhou Q, Yan N

Nature (2016) 537 pp. 191-196 [ DOI: doi:10.1038/nature19321 Pubmed: 27580036 ]

Sample:

Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
Voltage-gated calcium channel cav1.1 (500 kDa, Complex from Oryctolagus cuniculus)
2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
Calcium ion (40 Da, Ligand)
Voltage-dependent l-type calcium channel subunit beta-1 (22 kDa, Protein from Oryctolagus cuniculus)
Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
Voltage-dependent l-type calcium channel subunit beta-1 (11 kDa, Protein from Oryctolagus cuniculus)

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EMD-9518

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Cryo-EM map of RyR1 in a closed state (C1 conformer)

Release date: Aug. 24, 2016
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 5gky
Q-score: 0.317

Bai XC, Yan Z, Wu JP, Li ZQ, Yan N

Cell Res (2016) 26 pp. 995-1006 [ Pubmed: 27468892 DOI: doi:10.1038/cr.2016.89 ]

Sample:

Zinc ion (65 Da, Ligand)
Ryr1 in complex with fkbp12 (2 MDa, Complex)
Fkbp12 (Complex from Oryctolagus cuniculus)
Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
Ryr1 (Complex from Oryctolagus cuniculus)
Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Oryctolagus cuniculus)

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EMD-9519

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Cryo-EM map of RyR1 in a closed state (C3 conformer)

Release date: Aug. 24, 2016
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 5gkz
Q-score: 0.337

Bai XC, Yan Z, Wu JP, Li ZQ, Yan N

Cell Res (2016) 26 pp. 995-1006 [ Pubmed: 27468892 DOI: doi:10.1038/cr.2016.89 ]

Sample:

Zinc ion (65 Da, Ligand)
Ryr1 in complex with fkbp12 (2 MDa, Complex)
Fkbp12 (Complex from Oryctolagus cuniculus)
Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
Ryr1 (Complex from Oryctolagus cuniculus)
Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Oryctolagus cuniculus)

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EMD-9520

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Cryo-EM map of RyR1 in a closed state (C4 conformer)

Release date: Aug. 24, 2016
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 5gl0
Q-score: 0.309

Bai XC, Yan Z, Wu JP, Li ZQ, Yan N

Cell Res (2016) 26 pp. 995-1006 [ Pubmed: 27468892 DOI: doi:10.1038/cr.2016.89 ]

Sample:

Zinc ion (65 Da, Ligand)
Ryr1 in complex with fkbp12 (2 MDa, Complex)
Fkbp12 (Complex from Oryctolagus cuniculus)
Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
Ryr1 (Complex from Oryctolagus cuniculus)
Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Oryctolagus cuniculus)

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