Human Nav1.8 with A-803467, class I
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7we4
Q-score: 0.55
Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N
PNAS (2022) 119 pp. e2208211119-e2208211119 [ DOI: doi:10.1073/pnas.2208211119 Pubmed: 35858452 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel i (Complex from Homo sapiens)
- 5-(4-chlorophenyl)-~{n}-(3,5-dimethoxyphenyl)furan-2-carboxamide (357 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (220 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Human Nav1.8 with A-803467, class II
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7wel
Q-score: 0.487
Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N
PNAS (2022) 119 pp. e2208211119-e2208211119 [ DOI: doi:10.1073/pnas.2208211119 Pubmed: 35858452 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-(4-chlorophenyl)-~{n}-(3,5-dimethoxyphenyl)furan-2-carboxamide (357 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (220 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Sodium channel ii (Complex from Homo sapiens)
Human Nav1.8 with A-803467, class III
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7wfr
Q-score: 0.483
Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N
PNAS (2022) 119 pp. e2208211119-e2208211119 [ DOI: doi:10.1073/pnas.2208211119 Pubmed: 35858452 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-(4-chlorophenyl)-~{n}-(3,5-dimethoxyphenyl)furan-2-carboxamide (357 Da, Ligand)
- Sodium channel iii (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (220 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7wfw
Q-score: 0.471
Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N
PNAS (2022) 119 pp. e2208211119-e2208211119 [ DOI: doi:10.1073/pnas.2208211119 Pubmed: 35858452 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (220 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Sodium channel ii (Complex from Homo sapiens)
Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6agf
Q-score: 0.526
Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N
Science (2018) 362 [ Pubmed: 30190309 DOI: doi:10.1126/science.aau2486 ]
- Human sodium channel subunit beta-1 (Complex from Homo sapiens)
- Human sodium channel protein type 4 subunit alpha (Complex from Homo sapiens)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of human sodium channel protein type 4 subunit alpha and human sodium channel subunit beta-1 (200 kDa, Complex)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 4 subunit alpha (212 kDa, Protein from Homo sapiens)