Human R-type voltage-gated calcium channel Cav2.3 at 3.1 Angstrom resolution
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8epl
Q-score: 0.472
Yao X, Wang Y, Wang Z, Fan X, Wu D, Huang J, Mueller A, Gao S, Hu M, Robinson CV, Yu Y, Gao S, Yan N
Nat Commun (2022) 13 pp. 7358-7358 [ DOI: doi:10.1038/s41467-022-35026-6 Pubmed: 36446785 ]
- Voltage-dependent r-type calcium channel subunit alpha-1e (262 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Cav2.3 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
Human R-type voltage-gated calcium channel Cav2.3 CH2II-deleted mutant at 3.1 Angstrom resolution
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8epm
Q-score: 0.512
Yao X, Wang Y, Wang Z, Fan X, Wu D, Huang J, Mueller A, Gao S, Hu M, Robinson CV, Yu Y, Gao S, Yan N
Nat Commun (2022) 13 pp. 7358-7358 [ DOI: doi:10.1038/s41467-022-35026-6 Pubmed: 36446785 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent r-type calcium channel subunit alpha-1e (262 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cav2.3 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uhf
Q-score: 0.425
Cell Res (2022) 32 pp. 946-948 [ DOI: doi:10.1038/s41422-022-00663-5 Pubmed: 35477996 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- 1-(diphenylmethyl)-4-[(2e)-3-phenylprop-2-en-1-yl]piperazine (368 Da, Ligand)
- Cav1.3 (Complex from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1d (245 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
Human L-type voltage-gated calcium channel Cav1.3 at 3.0 Angstrom resolution
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7uhg
Q-score: 0.465
Cell Res (2022) 32 pp. 946-948 [ DOI: doi:10.1038/s41422-022-00663-5 Pubmed: 35477996 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cav1.3 (Complex from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit alpha-1d (245 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7mix
Q-score: 0.496
Nature (2021) 596 pp. 143-147 [ Pubmed: 34234349 DOI: doi:10.1038/s41586-021-03699-6 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Omega-conotoxin mviia (2 kDa, Protein from Conus magus)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Cav2.2-ziconotide (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Voltage-dependent n-type calcium channel subunit alpha-1b (262 kDa, Protein from Homo sapiens)
- Cav2.2 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
Human N-type voltage-gated calcium channel Cav2.2 at 3.1 Angstrom resolution
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7miy
Q-score: 0.472
Nature (2021) 596 pp. 143-147 [ Pubmed: 34234349 DOI: doi:10.1038/s41586-021-03699-6 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Voltage-dependent n-type calcium channel subunit alpha-1b (262 kDa, Protein from Homo sapiens)
- Cav2.2 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6m49
Q-score: 0.335
Yan R, Cao P, Song W, Qian H, Du X, Coates HW, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown AJ, Zhou Q, Yan C, Yan N
Science (2021) 371 [ Pubmed: 33446483 DOI: doi:10.1126/science.abb2224 ]
- 25-hydroxycholesterol (402 Da, Ligand)
- Scap and insig complex (Complex from Homo sapiens)
- Sterol regulatory element-binding protein cleavage-activating protein,sterol regulatory element-binding protein cleavage-activating protein (63 kDa, Protein from Homo sapiens)
- Insulin-induced gene 2 protein (24 kDa, Protein from Homo sapiens)
Cryo-EM structure of SLC40/ferroportin in complex with Fab
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6vyh
Q-score: 0.532
Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M
Nat Commun (2020) 11 pp. 5686-5686 [ DOI: doi:10.1038/s41467-020-19458-6 Pubmed: 33173040 ]
- 11f9 light-chain (23 kDa, Protein from Mus musculus)
- Solute carrier family 40 protein (63 kDa, Protein from Carlito syrichta)
- Cryo-em map of slc40/ferroportin in complex with fab (Complex from Carlito syrichta)
- Cobalt (ii) ion (58 Da, Ligand)
- 11f9 heavy-chain (25 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
Cryo-EM structure of SLC40/ferroportin with Fab in the presence of hepcidin
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6wik
Q-score: 0.384
Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M
Nat Commun (2020) 11 pp. 5686-5686 [ DOI: doi:10.1038/s41467-020-19458-6 Pubmed: 33173040 ]
- Cryo-em map of slc40/ferroportin with fab in the presence of hepcidin (Complex from Carlito syrichta)
- 11f9 fab heavy-chain (25 kDa, Protein from Mus musculus)
- 11f9 fab light-chain (23 kDa, Protein from Mus musculus)
- Solute carrier family 40 protein (63 kDa, Protein from Carlito syrichta)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6vwx
Q-score: 0.521
Gao S, Valinsky WC, On NC, Houlihan PR, Qu Q, Liu L, Pan X, Clapham DE, Yan N
PNAS (2020) 117 pp. 14187-14193 [ Pubmed: 32513729 DOI: doi:10.1073/pnas.1922903117 ]
- Nachbac (Complex from Bacillus halodurans C-125)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Bh1501 protein (31 kDa, Protein from Bacillus halodurans C-125)