Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7w9k
Q-score: 0.507
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Human voltage-gated sodium channel nav1.7 in complex with auxiliary beta subunits (279 MDa, Complex from Homo sapiens)
- (2s,3r,4e)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (421 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM structure of human Nav1.7(E406K)-beta1-beta2 complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7w9l
Q-score: 0.414
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Human voltage-gated sodium channel nav1.7 in complex with auxiliary beta subunits (279 MDa, Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7w9m
Q-score: 0.437
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Human voltage-gated sodium channel nav1.7 in complex with auxiliary beta subunits (279 MDa, Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- (1r,5r,6r,7r,9s,11s,12s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name) (319 Da, Ligand)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7w9p
Q-score: 0.456
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Human voltage-gated sodium channel nav1.7 in complex with auxiliary beta subunits (279 MDa, Complex from Homo sapiens)
- (2s,3r,4e)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (421 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7w9t
Q-score: 0.431
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Human nav1.7 in complex with beta1, beta2 and huwentoxin (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
Voltage-gated sodium channel Nav1.1 and beta4
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7dtd
Q-score: 0.428
Pan X, Li Z, Jin X, Zhao Y, Huang G, Huang X, Shen Z, Cao Y, Dong M, Lei J, Yan N
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2100066118 Pubmed: 33712547 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel subunit beta-4 (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 1 subunit alpha (233 kDa, Protein from Homo sapiens)
- Voltage-gated sodium channel (Complex from Homo sapiens)
voltage-gated sodium channel Nav1.5 with quinidine
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6lqa
Q-score: 0.438
Li Z, Jin X, Wu T, Huang G, Wu K, Lei J, Pan X, Yan N
Angew Chem Int Ed Engl (2021) 60 pp. 11474-11480 [ DOI: doi:10.1002/anie.202102196 Pubmed: 33684260 ]
- Quinidine (324 Da, Ligand)
- Voltage-gated sodium channel with drug (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 5 subunit alpha (231 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6vwx
Q-score: 0.521
Gao S, Valinsky WC, On NC, Houlihan PR, Qu Q, Liu L, Pan X, Clapham DE, Yan N
PNAS (2020) 117 pp. 14187-14193 [ Pubmed: 32513729 DOI: doi:10.1073/pnas.1922903117 ]
- Nachbac (Complex from Bacillus halodurans C-125)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Bh1501 protein (31 kDa, Protein from Bacillus halodurans C-125)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6vx3
Q-score: 0.463
Gao S, Valinsky WC, On NC, Houlihan PR, Qu Q, Liu L, Pan X, Clapham DE, Yan N
PNAS (2020) 117 pp. 14187-14193 [ Pubmed: 32513729 DOI: doi:10.1073/pnas.1922903117 ]
NaChBac-Nav1.7VSDII chimera in nanodisc
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6vxo
Q-score: 0.473
Gao S, Valinsky WC, On NC, Houlihan PR, Qu Q, Liu L, Pan X, Clapham DE, Yan N
PNAS (2020) 117 pp. 14187-14193 [ Pubmed: 32513729 DOI: doi:10.1073/pnas.1922903117 ]