Rabbit Cav1.1-Nifedipine Complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6jp5
Q-score: 0.39
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N
Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]
- Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (346 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Oryctolagus cuniculus)
- Cav1.1-drug complex (Complex)
- Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- Ethanolamine (61 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
Rabbit Cav1.1-Bay K8644 Complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6jp8
Q-score: 0.385
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N
Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]
- Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (118 kDa, Protein from Oryctolagus cuniculus)
- Cav1.1-drug complex (Complex)
- Methyl (4~{s})-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate (356 Da, Ligand)
- Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- Ethanolamine (61 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
Rabbit Cav1.1-Verapamil Complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6jpa
Q-score: 0.4
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N
Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]
- Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit beta-1 (57 kDa, Protein from Oryctolagus cuniculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (118 kDa, Protein from Oryctolagus cuniculus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Cav1.1-drug complex (Complex)
- (2s)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile (454 Da, Ligand)
- Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
- Ethanolamine (61 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit alpha-1s (172 kDa, Protein from Oryctolagus cuniculus)
Rabbit Cav1.1-Diltiazem Complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6jpb
Q-score: 0.397
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N
Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]
- Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
- Diltiazem (414 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (118 kDa, Protein from Oryctolagus cuniculus)
- Cav1.1-drug complex (Complex)
- Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- Ethanolamine (61 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit beta-1 (57 kDa, Protein from Oryctolagus cuniculus)
Molecular basis for pore blockade of human Sodium channel Nav1.2 by mu-conotoxin KIIIA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6j8e
Q-score: 0.477
Pan X, Li Z, Huang X, Huang G, Gao S, Shen H, Liu L, Lei J, Yan N
Science (2019) 363 pp. 1309-1313 [ DOI: doi:10.1126/science.aaw2999 Pubmed: 30765605 ]
- Nav1.2-beta2-kiiia (252 MDa, Complex)
- Kiiia (Complex from Conus kinoshitai)
- Sodium channel protein type 2 subunit alpha (Protein from Homo sapiens)
- Human voltage gated sodium channel sub-type 1.2 (Protein from Homo sapiens)
- Mu-conotoxin kiiia (Protein from Conus kinoshitai)
- Nav1.2-beta2 (Complex from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6j8g, 6j8h
Q-score: 0.495
Shen H, Liu D, Wu K, Lei J, Yan N
Science (2019) 363 pp. 1303-1308 [ Pubmed: 30765606 DOI: doi:10.1126/science.aaw2493 ]
- Complex of human voltage-gated sodium channel nav1.7 with auxiliary beta subunits, huwentoxin-iv and saxitoxin (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6j8i, 6j8j
Q-score: 0.46
Shen H, Liu D, Wu K, Lei J, Yan N
Science (2019) 363 pp. 1303-1308 [ Pubmed: 30765606 DOI: doi:10.1126/science.aaw2493 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of human voltage-gated sodium channel nav1.7 with auxiliary beta subunits, protx-ii and tetrodotoxin (Complex from Homo sapiens)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- (1r,5r,6r,7r,9s,11s,12s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name) (319 Da, Ligand)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6a90
Q-score: 0.56
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ Pubmed: 30049784 DOI: doi:10.1126/science.aau2596 ]
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana and dc1a (200 kDa, Complex)
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- Dc1a (Complex from Diguetia canities)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6a91
Q-score: 0.515
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ Pubmed: 30049784 DOI: doi:10.1126/science.aau2596 ]
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound with saxitoxin and dc1a (200 kDa, Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- Dc1a (Complex from Diguetia canities)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6a95
Q-score: 0.565
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ Pubmed: 30049784 DOI: doi:10.1126/science.aau2596 ]
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound with saxitoxin and dc1a (200 kDa, Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (1r,5r,6r,7r,9s,11s,12s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name) (319 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- Dc1a (Complex from Diguetia canities)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)