Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 9ikm
Q-score: 0.422
Cryo-EM Structure of GCN2 HRSL Domain
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 9bf3
Q-score: 0.517
Solorio-Kirpichyan KM, Golovenko D, Xiao F, Yan N, Korostelev AA, Korennykh AV
To Be Published
- Gcn2 hrsl domain (116 kDa, Complex from Kluyveromyces marxianus)
- Non-specific serine/threonine protein kinase (190 kDa, Protein from Kluyveromyces marxianus)
Resolution: 3.22 Å
EM Method: Helical reconstruction
Fitted PDBs: 9ikj
Q-score: 0.53
Wang T, Li Z, Xu K, Huang W, Huang G, Zhang QC, Yan N
PNAS (2024) 121 pp. e2417046121-e2417046121 [ DOI: doi:10.1073/pnas.2417046121 Pubmed: 39382995 ]
- Tlp-1a (Complex from algae metagenome)
- Tlp-1 (25 kDa, Protein from algae metagenome)
Resolution: 3.51 Å
EM Method: Helical reconstruction
Fitted PDBs: 9ikk
Q-score: 0.452
Wang T, Li Z, Xu K, Huang W, Huang G, Zhang QC, Yan N
PNAS (2024) 121 pp. e2417046121-e2417046121 [ DOI: doi:10.1073/pnas.2417046121 Pubmed: 39382995 ]
- Tlp-2 (25 kDa, Protein from algae metagenome)
- Tlp-1b (Complex from algae metagenome)
mycobacterial efflux pump, substrate-bound state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1n
Q-score: 0.541
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ DOI: doi:10.1073/pnas.2403421121 Pubmed: 39226350 ]
- Rifampicin (822 Da, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Cardiolipin (1 kDa, Ligand)
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
Cryo-EM structure of apo state human Cav3.2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayg
Q-score: 0.537
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
Cryo-EM structure of human Cav3.2 with TTA-A2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9ayh
Q-score: 0.52
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- 2-(4-cyclopropylphenyl)-n-{(1r)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide (378 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
Cryo-EM structure of human Cav3.2 with TTA-P2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9ayj
Q-score: 0.484
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- 3,5-dichloro-n-[(1-{[(4s)-2,2-dimethyloxan-4-yl]methyl}-4-fluoropiperidin-4-yl)methyl]benzamide (431 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
Cryo-EM structure of human Cav3.2 with ML218
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayk
Q-score: 0.519
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- 3,5-dichloro-n-{[(1r,5s,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide (369 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8wa2
Q-score: 0.457
Huang J, Tao H, Chen J, Shen Y, Lei J, Pan J, Yan C, Yan N
Cell (2024) 187 pp. 1733-1744.e12 [ Pubmed: 38552612 DOI: doi:10.1016/j.cell.2024.02.037 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Alpha-l-arabinofuranose (150 Da, Ligand)
- Mstax (6 kDa, Protein from synthetic construct)
- Alpha-d-galactopyranose (180 Da, Ligand)
- Mastigoneme (Cellular component from Chlamydomonas reinhardtii)
- Mst1 (206 kDa, Protein from Chlamydomonas reinhardtii)