Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 9dyh
Q-score: 0.476
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Best2 + glutamate open state (286 kDa, Complex from Homo sapiens)
BEST2 + glutamate closed state
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 9dyi
Q-score: 0.555
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Best2 + glutamate closed state (286 kDa, Complex from Homo sapiens)
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 9dyo
Q-score: 0.624
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Best2 + paba closed state (286 kDa, Complex from Homo sapiens)
Resolution: 2.31 Å
EM Method: Single-particle
Fitted PDBs: 9dyj
Q-score: 0.684
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Best2 + gaba open state (286 kDa, Complex from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 9dyl
Q-score: 0.623
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Bestrophin-1 (67 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Best1 + paba open state (338 kDa, Complex from Homo sapiens)
- 4-aminobenzoic acid (137 Da, Ligand)
BEST1 + PABA intermediate state
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 9dym
Q-score: 0.61
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Best1 + paba intermediate state (338 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Bestrophin-1 (67 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- 4-aminobenzoic acid (137 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Resolution: 2.44 Å
EM Method: Single-particle
Fitted PDBs: 9dyn
Q-score: 0.642
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- 4-aminobenzoic acid (137 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Best2 + paba open state (286 kDa, Complex from Homo sapiens)
Cryo-EM structure of human HCN3 channel with cAMP
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8io0
Q-score: 0.42
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 9ctq
Q-score: 0.659
Wang J, Owji AP, Kittredge A, Clark Z, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 8051-8051 [ Pubmed: 39277606 DOI: doi:10.1038/s41467-024-52039-5 ]
- Calcium ion (40 Da, Ligand)
- Bestrophin-1 (67 kDa, Protein from Homo sapiens)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gaba-bound homopentameric complex of best1 anion channel in fully open fffff state (337 kDa, Complex from Homo sapiens)
Best1 + GABA intermediate state 1
Resolution: 2.42 Å
EM Method: Single-particle
Fitted PDBs: 9ctr
Q-score: 0.651
Wang J, Owji AP, Kittredge A, Clark Z, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 8051-8051 [ Pubmed: 39277606 DOI: doi:10.1038/s41467-024-52039-5 ]
- Calcium ion (40 Da, Ligand)
- Gaba-bound homopentameric complex of best1 anion channel in intermediate state 1 icccc (337 kDa, Complex from Homo sapiens)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Bestrophin-1 (67 kDa, Protein from Homo sapiens)