CryoEM structure of LARGE1 bound to UDP
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9e1t
Q-score: 0.472
Joesph S, Spellmon N, Schnicker NJ, Xu Z, Yang T, Hopkins J, Chakravarthy S, Davulcu O, Anderson ME, Venzke D, Campbell KP
To Be Published
- Xylosyl- and glucuronyltransferase large1 (89 kDa, Protein from Homo sapiens)
- Large1 (Complex from Homo sapiens)
- Uridine-5'-diphosphate (404 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
Cryo-EM structure of human dimeric APJR-Gi complex with apelin-13.
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8xqe
Q-score: 0.304
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Dimeric apjr-gi complex with apelin-13 (Complex from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- G protein subunit alpha i1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
Cryo-EM structure of human monomeric APJR-Gi complex with apelin-13.
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8xqf
Q-score: 0.405
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- G protein subunit alpha i1 (40 kDa, Protein from Homo sapiens)
- Monomeric apjr-gi complex with apelin-13 (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
Cryo-EM structure of human dimeric Apelin receptor.
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8xqi
Q-score: 0.454
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Cholesterol (386 Da, Ligand)
- Homodimer of apelin receptor (Complex from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
Cryo-EM structure of human dimeric APJR complex with antagonistic antibody
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8xqj
Q-score: 0.444
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Cholesterol (386 Da, Ligand)
- Jn241 (17 kDa, Protein from Homo sapiens)
- Apjr complex with antibody (Complex from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
Cryo-EM structure of APJR complex with agonistic antibody
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8z74
Q-score: 0.394
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Apjr complex with antibody (Complex from Homo sapiens)
- Agonistic antibody (13 kDa, Protein from Homo sapiens)
Cryo-EM structure of APJR-Gi complex with agonistic antibody
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8z7j
Q-score: 0.388
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Agonistic antibody (13 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Apjr complexed with gi (Complex from Homo sapiens)
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 9dyh
Q-score: 0.476
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Best2 + glutamate open state (286 kDa, Complex from Homo sapiens)
BEST2 + glutamate closed state
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 9dyi
Q-score: 0.555
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Best2 + glutamate closed state (286 kDa, Complex from Homo sapiens)
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 9dyo
Q-score: 0.624
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Best2 + paba closed state (286 kDa, Complex from Homo sapiens)