Cardiac sodium channel with flecainide
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 6uz0
Q-score: 0.459
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ Pubmed: 31866066 DOI: doi:10.1016/j.cell.2019.11.041 ]
- Cardiac sodium channel complex with flecainide (250 kDa, Complex from Rattus norvegicus)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Flecainide (414 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6uz3
Q-score: 0.401
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ Pubmed: 31866066 DOI: doi:10.1016/j.cell.2019.11.041 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- Cardiac sodium channel apo structure (250 kDa, Complex from Rattus norvegicus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
EMDB: Cryo electron microscopy map of the ATP-gated rat P2X7 ion channel in the apo, closed state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6u9v
Q-score: 0.503
McCarthy AE, Yoshioka C, Mansoor SE
Cell (2019) 179 pp. 659-670.e13 [ DOI: doi:10.1016/j.cell.2019.09.017 Pubmed: 31587896 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- P2x purinoceptor 7 (69 kDa, Protein from Rattus norvegicus)
- P2x7 receptor ion channel (Complex from Rattus norvegicus)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
Cryo electron microscopy map of the ATP-gated rat P2X7 ion channel in the ATP-bound, open state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6u9w
Q-score: 0.523
McCarthy AE, Yoshioka C, Mansoor SE
Cell (2019) 179 pp. 659-670.e13 [ DOI: doi:10.1016/j.cell.2019.09.017 Pubmed: 31587896 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- P2x purinoceptor 7 (69 kDa, Protein from Rattus norvegicus)
- P2x7 receptor ion channel (Complex from Rattus norvegicus)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 6pz9
Q-score: 0.427
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ Pubmed: 31343405 DOI: doi:10.7554/eLife.46417 ]
- Katp (Complex from Rattus norvegicus)
- Repaglinide (452 Da, Ligand)
- Sur1 (Complex from Cricetus cricetus)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Katp-rpg-atp (Complex)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 6pza
Q-score: 0.26
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ Pubmed: 31343405 DOI: doi:10.7554/eLife.46417 ]
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Kntp (Complex from Rattus norvegicus)
- Sur1 (Complex from Cricetus cricetus)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Katp-rpg-atp (Complex)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
Cryo-EM structure of the pancreatic beta-cell SUR1 Apo state
Resolution: 4.55 Å
EM Method: Single-particle
Fitted PDBs: 6pzb
Q-score: 0.304
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ Pubmed: 31343405 DOI: doi:10.7554/eLife.46417 ]
- Sur1 (Complex from Cricetus cricetus)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to carbamazepine
Resolution: 4.34 Å
EM Method: Single-particle
Fitted PDBs: 6pzc
Q-score: 0.206
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ Pubmed: 31343405 DOI: doi:10.7554/eLife.46417 ]
- Sur1 (Complex from Cricetus cricetus)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP only
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6pzi
Q-score: 0.312
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ Pubmed: 31343405 DOI: doi:10.7554/eLife.46417 ]
- Sur1 (Complex from Cricetus cricetus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
Cryo-EM structure of AAV-2 in complex with AAVR PKD domains 1 and 2
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 6nz0
Q-score: 0.665
Meyer NL, Hu G, Davulcu O, Xie Q, Noble AJ, Yoshioka C, Gingerich DS, Trzynka A, David L, Stagg SM, Chapman MS
eLife (2019) 8 [ DOI: doi:10.7554/eLife.44707 Pubmed: 31115336 ]
- Binary complex of aav-2 with a fragment of its cellular receptor, aavr or dyslexia-associated protein kiaa0319-like protein. (Complex from Homo sapiens)
- Adeno-associated virus - 2 (22 kDa, Virus from Adeno-associated virus - 2)
- Capsid protein vp1 (82 kDa, Protein from Adeno-associated virus - 2)
- Magnesium ion (24 Da, Ligand)
- Dyslexia-associated protein kiaa0319-like protein (31 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)