Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 6pz9
Q-score: 0.427
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ DOI: doi:10.7554/eLife.46417 Pubmed: 31343405 ]
- Sur1 (Complex from Cricetus cricetus)
- Repaglinide (452 Da, Ligand)
- Katp (Complex from Rattus norvegicus)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- Katp-rpg-atp (Complex)
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 6pza
Q-score: 0.26
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ DOI: doi:10.7554/eLife.46417 Pubmed: 31343405 ]
- Sur1 (Complex from Cricetus cricetus)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Kntp (Complex from Rattus norvegicus)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Katp-rpg-atp (Complex)
Cryo-EM structure of the pancreatic beta-cell SUR1 Apo state
Resolution: 4.55 Å
EM Method: Single-particle
Fitted PDBs: 6pzb
Q-score: 0.304
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ DOI: doi:10.7554/eLife.46417 Pubmed: 31343405 ]
- Sur1 (Complex from Cricetus cricetus)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to carbamazepine
Resolution: 4.34 Å
EM Method: Single-particle
Fitted PDBs: 6pzc
Q-score: 0.206
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ DOI: doi:10.7554/eLife.46417 Pubmed: 31343405 ]
- Sur1 (Complex from Cricetus cricetus)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP only
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6pzi
Q-score: 0.312
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ DOI: doi:10.7554/eLife.46417 Pubmed: 31343405 ]
- Sur1 (Complex from Cricetus cricetus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
Cryo-EM structure of the pancreatic beta-cell KATP channel bound to ATP and glibenclamide
Resolution: 3.63 Å
EM Method: Single-particle
Fitted PDBs: 6baa
Q-score: 0.325
Martin GM, Kandasamy B, DiMaio F, Yoshioka C, Shyng SL
eLife (2017) 6 [ Pubmed: 29035201 DOI: doi:10.7554/eLife.31054 ]
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (Complex)
- Pancreatic beta-cell atp-sensitive k+ channel (katp) (950 kDa, Complex from Rattus norvegicus)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- Atp-sensitive k+ channel subunit kir6.2 (Complex)
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
Resolution: 6.3 Å
EM Method: Single-particle
Fitted PDBs: 5twv
Q-score: 0.231
Martin GM, Yoshioka C, Rex EA, Fay JF, Xie Q, Whorton MR, Chen JZ, Shyng SL
eLife (2017) 6 [ DOI: doi:10.7554/eLife.24149 Pubmed: 28092267 ]
- Sur1 (Complex from Cricetus cricetus)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Kir6.2 (Complex from Rattus norvegicus)
- Atp-sensitive k+ channel complex sur1/kir6.2 (Complex from Rattus norvegicus)
- Atp-binding cassette sub-family c member 8 (178 kDa, Protein from Cricetus cricetus)