Cardiac sodium channel with flecainide
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 6uz0
Q-score: 0.459
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ Pubmed: 31866066 DOI: doi:10.1016/j.cell.2019.11.041 ]
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- Flecainide (414 Da, Ligand)
- Cardiac sodium channel complex with flecainide (250 kDa, Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6uz3
Q-score: 0.401
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ Pubmed: 31866066 DOI: doi:10.1016/j.cell.2019.11.041 ]
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Cardiac sodium channel apo structure (250 kDa, Complex from Rattus norvegicus)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
EMDB: Cryo electron microscopy map of the ATP-gated rat P2X7 ion channel in the apo, closed state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6u9v
Q-score: 0.503
McCarthy AE, Yoshioka C, Mansoor SE
Cell (2019) 179 pp. 659-670.e13 [ DOI: doi:10.1016/j.cell.2019.09.017 Pubmed: 31587896 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- P2x7 receptor ion channel (Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- P2x purinoceptor 7 (69 kDa, Protein from Rattus norvegicus)
Cryo electron microscopy map of the ATP-gated rat P2X7 ion channel in the ATP-bound, open state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6u9w
Q-score: 0.523
McCarthy AE, Yoshioka C, Mansoor SE
Cell (2019) 179 pp. 659-670.e13 [ DOI: doi:10.1016/j.cell.2019.09.017 Pubmed: 31587896 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- P2x7 receptor ion channel (Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- P2x purinoceptor 7 (69 kDa, Protein from Rattus norvegicus)
Resolution: 5.97 Å
EM Method: Single-particle
Fitted PDBs: 6mm9
Q-score: 0.211
Jalali-Yazdi F, Chowdhury S, Yoshioka C, Gouaux E
Cell (2018) 175 pp. 1520-1532.e15 [ DOI: doi:10.1016/j.cell.2018.10.043 Pubmed: 30500536 ]
- Glutamate receptor ionotropic, nmda 2a (93 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Diheteromeric nmda receptor glun1/glun2a in the '1-knuckle' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at ph 6.1 (500 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (94 kDa, Protein from Rattus norvegicus)
Resolution: 6.31 Å
EM Method: Single-particle
Fitted PDBs: 6mma
Q-score: 0.184
Jalali-Yazdi F, Chowdhury S, Yoshioka C, Gouaux E
Cell (2018) 175 pp. 1520-1532.e15 [ DOI: doi:10.1016/j.cell.2018.10.043 Pubmed: 30500536 ]
- Diheteromeric nmda receptor glun1/glun2a in the 'extended' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at ph 6.1 (500 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2a (93 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (94 kDa, Protein from Rattus norvegicus)
Resolution: 12.7 Å
EM Method: Single-particle
Fitted PDBs: 6mmb
Q-score: 0.068
Jalali-Yazdi F, Chowdhury S, Yoshioka C, Gouaux E
Cell (2018) 175 pp. 1520-1532.e15 [ DOI: doi:10.1016/j.cell.2018.10.043 Pubmed: 30500536 ]
- Glutamate receptor ionotropic, nmda 2a (93 kDa, Protein from Rattus norvegicus)
- Diheteromeric nmda receptor glun1/glun2a in the 'super-splayed' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at ph 6.1 (500 kDa, Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (94 kDa, Protein from Rattus norvegicus)
Resolution: 6.23 Å
EM Method: Single-particle
Fitted PDBs: 6mmg
Q-score: 0.124
Jalali-Yazdi F, Chowdhury S, Yoshioka C, Gouaux E
Cell (2018) 175 pp. 1520-1532.e15 [ DOI: doi:10.1016/j.cell.2018.10.043 Pubmed: 30500536 ]
- Diheteromeric nmda receptor glun1/glun2a in the '2-knuckle-symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 milliomolar edta, and at ph 7.4 (500 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2a (93 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (94 kDa, Protein from Rattus norvegicus)
Resolution: 8.21 Å
EM Method: Single-particle
Fitted PDBs: 6mmh
Q-score: 0.145
Jalali-Yazdi F, Chowdhury S, Yoshioka C, Gouaux E
Cell (2018) 175 pp. 1520-1532.e15 [ DOI: doi:10.1016/j.cell.2018.10.043 Pubmed: 30500536 ]
- Glutamate receptor ionotropic, nmda 2a (93 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Diheteromeric nmda receptor glun1/glun2a in the 'extended-2' conformation, in complex with glycine and glutamate, in the presence of 1 milliomolar zinc chloride, and at ph 7.4 (500 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (94 kDa, Protein from Rattus norvegicus)
Resolution: 8.93 Å
EM Method: Single-particle
Fitted PDBs: 6mmi
Q-score: 0.133
Jalali-Yazdi F, Chowdhury S, Yoshioka C, Gouaux E
Cell (2018) 175 pp. 1520-1532.e15 [ DOI: doi:10.1016/j.cell.2018.10.043 Pubmed: 30500536 ]
- Glutamate receptor ionotropic, nmda 2a (93 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Diheteromeric nmda receptor glun1/glun2a in the 'splayed-open' conformation, in complex with glycine and glutamate, in the presence of 1 milliomolar zinc chloride, and at ph 7.4 (500 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (94 kDa, Protein from Rattus norvegicus)