Cardiac sodium channel with flecainide
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 6uz0
Q-score: 0.459
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ Pubmed: 31866066 DOI: doi:10.1016/j.cell.2019.11.041 ]
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- Flecainide (414 Da, Ligand)
- Cardiac sodium channel complex with flecainide (250 kDa, Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6uz3
Q-score: 0.401
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ Pubmed: 31866066 DOI: doi:10.1016/j.cell.2019.11.041 ]
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Cardiac sodium channel apo structure (250 kDa, Complex from Rattus norvegicus)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo electron microscopy map of the ATP-gated rat P2X7 ion channel in the ATP-bound, open state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6u9w
Q-score: 0.523
McCarthy AE, Yoshioka C, Mansoor SE
Cell (2019) 179 pp. 659-670.e13 [ DOI: doi:10.1016/j.cell.2019.09.017 Pubmed: 31587896 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- P2x7 receptor ion channel (Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- P2x purinoceptor 7 (69 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 6pz9
Q-score: 0.427
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ DOI: doi:10.7554/eLife.46417 Pubmed: 31343405 ]
- Sur1 (Complex from Cricetus cricetus)
- Repaglinide (452 Da, Ligand)
- Katp (Complex from Rattus norvegicus)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- Katp-rpg-atp (Complex)
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 6pza
Q-score: 0.26
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ DOI: doi:10.7554/eLife.46417 Pubmed: 31343405 ]
- Sur1 (Complex from Cricetus cricetus)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Kntp (Complex from Rattus norvegicus)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Katp-rpg-atp (Complex)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6dzz
Q-score: 0.336
Coleman JA, Yang D, Zhao Z, Wen PC, Yoshioka C, Tajkhorshid E, Gouaux E
Nature (2019) 569 pp. 141-145 [ DOI: doi:10.1038/s41586-019-1135-1 Pubmed: 31019304 ]
- 15b8 antibody heavy chain (12 kDa, Protein from Mus musculus)
- Serotonin transporter (Complex from Homo sapiens)
- 15b8 fab (Complex from Mus musculus)
- Human serotonin transporter in complex with fab bound to ibogaine (Complex)
- Sodium-dependent serotonin transporter (61 kDa, Protein from Homo sapiens)
- (5beta)-12-methoxyibogamine (310 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- 15b8 antibody light chain (11 kDa, Protein from Mus musculus)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6dw0
Q-score: 0.355
Phulera S, Zhu H, Yu J, Claxton DP, Yoder N, Yoshioka C, Gouaux E
eLife (2018) 7 [ Pubmed: 30044221 DOI: doi:10.7554/eLife.39383 ]
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Rattus norvegicus)
- Triheteromeric alpha1-beta1-gamma2 gabaa receptor (Complex from Rattus norvegicus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 (46 kDa, Protein from Rattus norvegicus)
- Gamma-aminobutyric acid receptor subunit beta-1,gamma-aminobutyric acid receptor subunit beta-1 (44 kDa, Protein from Rattus norvegicus)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6dw1
Q-score: 0.511
Phulera S, Zhu H, Yu J, Claxton DP, Yoder N, Yoshioka C, Gouaux E
eLife (2018) 7 [ Pubmed: 30044221 DOI: doi:10.7554/eLife.39383 ]
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Rattus norvegicus)
- Triheteromeric alpha1-beta1-gamma2 gabaa receptor (Complex from Rattus norvegicus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 (46 kDa, Protein from Rattus norvegicus)
- Gamma-aminobutyric acid receptor subunit beta-1,gamma-aminobutyric acid receptor subunit beta-1 (44 kDa, Protein from Rattus norvegicus)
Structure of an acid sensing ion channel in a resting state at high pH
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6ave
Q-score: 0.393
Nature (2018) 555 pp. 397-401 [ Pubmed: 29513651 DOI: doi:10.1038/nature25782 ]
- Acid sensing ion channel 1a (180 kDa, Complex from Gallus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acid-sensing ion channel 1 (60 kDa, Protein from Gallus gallus)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6bfu
Q-score: 0.449
Xiong X, Tortorici MA, Snijder J, Yoshioka C, Walls AC, Li W, McGuire AT, Rey FA, Bosch BJ, Veesler D
J Virol (2018) 92 [ DOI: doi:10.1128/JVI.01628-17 Pubmed: 29093093 ]