Cryo-EM structure of the tethered agonist-bound human PAR1-Gq complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xor
Q-score: 0.513
Guo J, Zhou YL, Yang Y, Guo S, You E, Xie X, Jiang Y, Mao C, Xu HE, Zhang Y
Cell Res (2024) 34 pp. 725-734 [ Pubmed: 38997424 DOI: doi:10.1038/s41422-024-00997-2 ]
- G(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (32 kDa, Protein from Mus musculus)
- Scfv16 (Complex from Homo sapiens)
- Gi1-gq chimeric (Complex from Mus musculus)
- Proteinase-activated receptor 1 lgbit (58 kDa, Protein from Homo sapiens)
- Cryo-em structure of ligand-bound form of the receptor in complex with the transducer (Complex from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus)
- G subunit q (gi1-gq chimeric) (41 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Proteinase-activated receptor 1 (Complex)
- G(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
Cryo-EM structure of the tethered agonist-bound human PAR1-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xos
Q-score: 0.48
Guo J, Zhou YL, Yang Y, Guo S, You E, Xie X, Jiang Y, Mao C, Xu HE, Zhang Y
Cell Res (2024) 34 pp. 725-734 [ Pubmed: 38997424 DOI: doi:10.1038/s41422-024-00997-2 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Proteinase-activated receptor 1 lgbit (58 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus)
- Tethered agonist-bound human par1-gi complex (Complex from Homo sapiens)
- Scfv16 (40 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7fig
Q-score: 0.377
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE
Nature (2021) 598 pp. 688-692 [ Pubmed: 34552239 DOI: doi:10.1038/s41586-021-03924-2 ]
- Camelid antibody vhh fragment nb35 (14 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gs protein (Complex from Bos taurus)
- Choriogonadotropin receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Antibody (Complex from Lama glama)
- Luteinizing hormone (Complex from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- Glycoprotein hormones alpha chain (13 kDa, Protein from Homo sapiens)
- Lutropin-choriogonadotropic hormone receptor (78 kDa, Protein from Homo sapiens)
- Choriogonadotropin subunit beta 3 (17 kDa, Protein from Homo sapiens)
- Chorionic gonadotropin (Complex from Homo sapiens)
luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7fih
Q-score: 0.382
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE
Nature (2021) 598 pp. 688-692 [ Pubmed: 34552239 DOI: doi:10.1038/s41586-021-03924-2 ]
- 5-azanyl-n-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide (514 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex (Complex)
- Engineered guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- Choriogonadotropin receptor (Complex from Homo sapiens)
- Glycoprotein hormones alpha chain (12 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Luteinizing hormone (Complex from Homo sapiens)
- Lutropin-choriogonadotropic hormone receptor (78 kDa, Protein from Homo sapiens)
- Choriogonadotropin subunit beta 3 (17 kDa, Protein from Homo sapiens)
- Chorionic gonadotropin (Complex from Homo sapiens)
- Gs proteins (Complex from Bos taurus)
luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-Gs complex
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7fii
Q-score: 0.326
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE
Nature (2021) 598 pp. 688-692 [ Pubmed: 34552239 DOI: doi:10.1038/s41586-021-03924-2 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Engineered guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- Lutropin-choriogonadotropic hormone receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-gs complex (Complex)
- Glycoprotein hormones alpha chain (13 kDa, Protein from Homo sapiens)
- Glycoprotein hormones alpha chain (Complex from Homo sapiens)
- Choriogonadotropin subunit beta 3 (17 kDa, Protein from Homo sapiens)
- Lutropin-choriogonadotropic hormone receptor (78 kDa, Protein from Homo sapiens)
- Choriogonadotropin subunit beta 3 (Complex from Homo sapiens)
- Gs proteins (Complex from Bos taurus)
luteinizing hormone/choriogonadotropin receptor
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7fij
Q-score: 0.247
Structure of COVID-19 RNA-dependent RNA polymerase bound to suramin
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 7d4f
Q-score: 0.608
Yin W, Luan X, Li Z, Zhou Z, Wang Q, Gao M, Wang X, Zhou F, Shi J, You E, Liu M, Wang Q, Jiang Y, Jiang H, Xiao G, Zhang L, Yu X, Zhang S, Eric Xu H
Nat Struct Mol Biol (2021) 28 pp. 319-325 [ DOI: doi:10.1038/s41594-021-00570-0 Pubmed: 33674802 ]
- Non-structural protein 8 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Covid-19 rdrp complex bound to suramin (Complex from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- 8-(3-(3-aminobenzamido)-4-methylbenzamido)naphthalene-1,3,5-trisulfonic acid (635 Da, Ligand)
- Rna-directed rna polymerase (107 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)