Cryo-EM co-structure of AcrB with the CU032 efflux pump inhibitor
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 9bfh
Q-score: 0.625
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- H6pd (Complex from Homo sapiens)
- (2s)-1-[(3r)-3-aminopyrrolidin-1-yl]-3-(3,4-dichlorophenoxy)propan-2-ol (305 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- Water (18 Da, Ligand)
Cryo-EM co-structure of AcrB with the EPM35 efflux pump inhibitor
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 9bfm
Q-score: 0.609
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- H6pd (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- (2s)-1-(3,4-dichlorophenoxy)-3-(4-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}piperidin-1-yl)propan-2-ol (465 Da, Ligand)
Cryo-EM co-structure of AcrB with the CU232 efflux pump inhibitor
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 9bfn
Q-score: 0.604
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- (2r)-1-(4-aminopiperidin-1-yl)-3-[3-(trifluoromethyl)phenoxy]propan-2-ol (318 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- H6pd (Complex from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM co-structure of AcrB with CU244
Resolution: 2.44 Å
EM Method: Single-particle
Fitted PDBs: 9bft
Q-score: 0.658
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- (2s)-1-{[(1r,5r)-3-azabicyclo[3.1.0]hexan-6-yl]amino}-3-(3,5-dichlorophenoxy)propan-2-ol (317 Da, Ligand)
- H6pd (Complex from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM structure of a full-length, native Drp1 dimer
Resolution: 5.97 Å
EM Method: Single-particle
Fitted PDBs: 8t1h
Q-score: 0.09
Rochon K, Bauer BL, Roethler NA, Buckley Y, Su CC, Huang W, Ramachandran R, Stoll MSK, Yu EW, Taylor DJ, Mears JA
Nat Commun (2024) 15 pp. 1328-1328 [ Pubmed: 38351080 DOI: doi:10.1038/s41467-024-45524-4 ]
- Dynamin-1-like protein (81 kDa, Protein from Homo sapiens)
- Dimer complex of native, full length drp1 (164 kDa, Complex from Homo sapiens)
Cryo-EM structure of NKCC1 Fu_CTD
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8ste
Q-score: 0.493
Moseng MA, Su CC, Rios K, Cui M, Lyu M, Glaza P, Klenotic PA, Delpire E, Yu EW
Sci Adv (2022) 8 pp. eabq0952- [ Pubmed: 36306358 DOI: doi:10.1126/sciadv.abq0952 ]
- Solute carrier family 12 member 2 (45 kDa, Protein from Homo sapiens)
- 5-(aminosulfonyl)-4-chloro-2-[(2-furylmethyl)amino]benzoic acid (330 Da, Ligand)
- Nkcc1_fu_ctd (Complex from Homo sapiens)
Cryo-EM structure of human liver glucosidase II
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8emr
Q-score: 0.512
Su CC, Lyu M, Zhang Z, Miyagi M, Huang W, Taylor DJ, Yu EW
Cell Rep (2023) 42 pp. 112609-112609 [ DOI: doi:10.1016/j.celrep.2023.112609 Pubmed: 37289586 ]
- Glucosidase ii (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Neutral alpha-glucosidase ab (106 kDa, Protein from Homo sapiens)
- Glucosidase 2 subunit beta (59 kDa, Protein from Homo sapiens)
Cryo-EM structure of human liver glycogen phosphorylase
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8ems
Q-score: 0.536
Su CC, Lyu M, Zhang Z, Miyagi M, Huang W, Taylor DJ, Yu EW
Cell Rep (2023) 42 pp. 112609-112609 [ DOI: doi:10.1016/j.celrep.2023.112609 Pubmed: 37289586 ]
- Glycogen phosphorylase (Complex from Homo sapiens)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- Glycogen phosphorylase, liver form (95 kDa, Protein from Homo sapiens)
Cryo-EM analysis of the human aldehyde oxidase from liver
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8emt
Q-score: 0.464
Su CC, Lyu M, Zhang Z, Miyagi M, Huang W, Taylor DJ, Yu EW
Cell Rep (2023) 42 pp. 112609-112609 [ DOI: doi:10.1016/j.celrep.2023.112609 Pubmed: 37289586 ]
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Aldehyde oxidase (148 kDa, Protein from Homo sapiens)
- Dioxothiomolybdenum(vi) ion (161 Da, Ligand)
- Phosphonic acidmono-(2-amino-5,6-dimercapto-4-oxo-3,7,8a,9,10,10a-hexahydro-4h-8-oxa-1,3,9,10-tetraaza-anthracen-7-ylmethyl)ester (395 Da, Ligand)
- Aldehyde oxidase (Complex from Homo sapiens)
- Flavin-adenine dinucleotide (785 Da, Ligand)
Glutamate dehydrogenase 1 from human liver
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7uzm
Q-score: 0.439
Su CC, Lyu M, Zhang Z, Miyagi M, Huang W, Taylor DJ, Yu EW
Cell Rep (2023) 42 pp. 112609-112609 [ DOI: doi:10.1016/j.celrep.2023.112609 Pubmed: 37289586 ]
- Glutamate dehydrogenase 1, mitochondrial (61 kDa, Protein from Homo sapiens)
- Glutamate dehydrogenase 1 (Complex from Homo sapiens)