Mycolicibacterium smegmatis MmpL5-AcpM structure
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 9dp6
Q-score: 0.535
Maharjan R, Klenotic PA, Zhang Z, Yu EW
To Be Published
- Mmpl5-acpm (Complex from Mycolicibacterium smegmatis)
- Mmpl5 protein (105 kDa, Protein from Mycolicibacterium smegmatis)
- Meromycolate extension acyl carrier protein (10 kDa, Protein from Mycolicibacterium smegmatis)
- 4'-phosphopantetheine (358 Da, Ligand)
Cryo-EM co-structure of AcrB with the CU032 efflux pump inhibitor
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 9bfh
Q-score: 0.625
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- H6pd (Complex from Homo sapiens)
- (2s)-1-[(3r)-3-aminopyrrolidin-1-yl]-3-(3,4-dichlorophenoxy)propan-2-ol (305 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- Water (18 Da, Ligand)
Cryo-EM co-structure of AcrB with the EPM35 efflux pump inhibitor
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 9bfm
Q-score: 0.609
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- H6pd (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- (2s)-1-(3,4-dichlorophenoxy)-3-(4-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}piperidin-1-yl)propan-2-ol (465 Da, Ligand)
Cryo-EM co-structure of AcrB with the CU232 efflux pump inhibitor
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 9bfn
Q-score: 0.604
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- (2r)-1-(4-aminopiperidin-1-yl)-3-[3-(trifluoromethyl)phenoxy]propan-2-ol (318 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- H6pd (Complex from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM co-structure of AcrB with CU244
Resolution: 2.44 Å
EM Method: Single-particle
Fitted PDBs: 9bft
Q-score: 0.658
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- (2s)-1-{[(1r,5r)-3-azabicyclo[3.1.0]hexan-6-yl]amino}-3-(3,5-dichlorophenoxy)propan-2-ol (317 Da, Ligand)
- H6pd (Complex from Homo sapiens)
- Water (18 Da, Ligand)
human liver mitochondrial Medium-chain specific acyl-CoA dehydrogenase
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8sgp
Q-score: 0.587
Zhang Z, Tringides ML, Morgan CE, Miyagi M, Mears JA, Hoppel CL, Yu EW
Mol.Cell Proteomics (2023) 22 pp. 100666-100666 [ DOI: doi:10.1016/j.mcpro.2023.100666 Pubmed: 37839702 ]
human liver mitochondrial Isovaleryl-CoA dehydrogenase
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8sgr
Q-score: 0.559
Zhang Z, Tringides ML, Morgan CE, Miyagi M, Mears JA, Hoppel CL, Yu EW
Mol.Cell Proteomics (2023) 22 pp. 100666-100666 [ DOI: doi:10.1016/j.mcpro.2023.100666 Pubmed: 37839702 ]
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Isovaleryl-coa dehydrogenase, mitochondrial (46 kDa, Protein from Homo sapiens)
- Isovaleryl-coa dehydrogenase (Complex from Homo sapiens)
human liver mitochondrial Short-chain specific acyl-CoA dehydrogenase
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8sgs
Q-score: 0.506
Zhang Z, Tringides ML, Morgan CE, Miyagi M, Mears JA, Hoppel CL, Yu EW
Mol.Cell Proteomics (2023) 22 pp. 100666-100666 [ DOI: doi:10.1016/j.mcpro.2023.100666 Pubmed: 37839702 ]
- Coenzyme a (767 Da, Ligand)
- Short-chain specific acyl-coa dehydrogenase (Complex from Homo sapiens)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Short-chain specific acyl-coa dehydrogenase, mitochondrial (44 kDa, Protein from Homo sapiens)
human liver mitochondrial Catalase
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8sgv
Q-score: 0.594
Zhang Z, Tringides ML, Morgan CE, Miyagi M, Mears JA, Hoppel CL, Yu EW
Mol.Cell Proteomics (2023) 22 pp. 100666-100666 [ DOI: doi:10.1016/j.mcpro.2023.100666 Pubmed: 37839702 ]
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Catalase (59 kDa, Protein from Homo sapiens)
- Catalase (Complex from Homo sapiens)
human liver mitochondrial Aldehyde dehydrogenase ALDH2
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8shs
Q-score: 0.556
Zhang Z, Tringides ML, Morgan CE, Miyagi M, Mears JA, Hoppel CL, Yu EW
Mol.Cell Proteomics (2023) 22 pp. 100666-100666 [ DOI: doi:10.1016/j.mcpro.2023.100666 Pubmed: 37839702 ]
- Aldehyde dehydrogenase, mitochondrial (56 kDa, Protein from Homo sapiens)
- Aldh2 (Complex from Homo sapiens)